Effect of sonocrystallization on the habit and structure of gemfibrozil crystals

Rita Ambrus, Nima N. Amirzadi, Peter Sipos, Piroska Szabó-Révész

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Specially engineered drug particles can solve solubility and formulation problems, which are major challenges for the pharmaceutical industry. Ultrasound irradiation induces acoustic streaming, and highly localized temperature and pressure within the fluid, which can lead to a reduction in crystal size and the inhibition of agglomeration. This study covers properties inherent to particle engineering as well as methods for microparticle production and characterization. Melt emulsification and solvent diffusion using ultrasound to complete with drying are presented on the example of poorly water-soluble Gemfibrozil. Differences in particle size were found depending on the processing parameters applied. During structural characterizations, strong interactions were detected between the drug and the stabilizers. Amorphous or crystalline Gemfibrozil could be obtained.

Original languageEnglish
Pages (from-to)827-832
Number of pages6
JournalChemical Engineering and Technology
Volume33
Issue number5
DOIs
Publication statusPublished - May 1 2010

Keywords

  • Crystallization
  • Microstructure
  • Morphology

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering

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