Effect of soluble immune complexes on Fc and C3 receptor-dependent phagocytosis by human monocytes

M. Kavai, M. Sandor, G. Szegedi, G. Füst, J. Gergely

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The capacity was studied of bovine serum albumin (BSA) rabbit anti-BSA and ovalbumin (OA) rabbit anti-OA immune complexes of different composition to inhibit the Fc receptor-dependent adherence and phagocytosis of sensitized sheep red blood cells by human monocytes. Parallel experiments were performed on the ability of the immune but complement-reacted complexes to inhibit the C3 receptor-dependent phagocytosis of C3-coated yeast particles. The extent of inhibition of both the Fc and C3 receptor-dependent phagocytosis was proportional to the antibody avidity of the complex used. Immune complexes made at equivalence and at moderate antibody excess markedly inhibited both types of phagocytosis, whereas those made at moderate antigen excess had only a weak inhibitory effect. These findings can be explained by the correlation between the Fc receptor-binding and complement-activating capacities of immune complexes of different composition. An alternative explanation, however, is also discussed.

Original languageEnglish
Pages (from-to)599-606
Number of pages8
JournalImmunology
Volume44
Issue number3
Publication statusPublished - Dec 29 1981

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Effect of soluble immune complexes on Fc and C3 receptor-dependent phagocytosis by human monocytes'. Together they form a unique fingerprint.

  • Cite this