Effect of sodium and potassium ions on the activity of human antithrombin-heparin cofactor

R. Machovich, György Blaskó, Ágnes Himer, Károly Szikla

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A method was developed for partial purification of human antithrombin-heparin cofactor and the effect of sodium and potassium ions on its activity was determined. It was found that the thrombin-antithrombin complex formation facilitated with heparin was further accelerated by sodium or potassium chloride. The rate of thrombin inactivation showed a maximum between 0.1 and 0.2 M ion concentration in the presence of 0.012 units heparin per ml.

Original languageEnglish
Pages (from-to)305-313
Number of pages9
JournalThrombosis Research
Volume7
Issue number2
DOIs
Publication statusPublished - 1975

Fingerprint

Antithrombins
Human Activities
Heparin
Potassium
Sodium
Ions
Potassium Chloride
Sodium Chloride
Thrombin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

Cite this

Effect of sodium and potassium ions on the activity of human antithrombin-heparin cofactor. / Machovich, R.; Blaskó, György; Himer, Ágnes; Szikla, Károly.

In: Thrombosis Research, Vol. 7, No. 2, 1975, p. 305-313.

Research output: Contribution to journalArticle

Machovich, R. ; Blaskó, György ; Himer, Ágnes ; Szikla, Károly. / Effect of sodium and potassium ions on the activity of human antithrombin-heparin cofactor. In: Thrombosis Research. 1975 ; Vol. 7, No. 2. pp. 305-313.
@article{ab17b19b8a884d3a8816583b5e1eeb23,
title = "Effect of sodium and potassium ions on the activity of human antithrombin-heparin cofactor",
abstract = "A method was developed for partial purification of human antithrombin-heparin cofactor and the effect of sodium and potassium ions on its activity was determined. It was found that the thrombin-antithrombin complex formation facilitated with heparin was further accelerated by sodium or potassium chloride. The rate of thrombin inactivation showed a maximum between 0.1 and 0.2 M ion concentration in the presence of 0.012 units heparin per ml.",
author = "R. Machovich and Gy{\"o}rgy Blask{\'o} and {\'A}gnes Himer and K{\'a}roly Szikla",
year = "1975",
doi = "10.1016/0049-3848(75)90189-9",
language = "English",
volume = "7",
pages = "305--313",
journal = "Thrombosis Research",
issn = "0049-3848",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Effect of sodium and potassium ions on the activity of human antithrombin-heparin cofactor

AU - Machovich, R.

AU - Blaskó, György

AU - Himer, Ágnes

AU - Szikla, Károly

PY - 1975

Y1 - 1975

N2 - A method was developed for partial purification of human antithrombin-heparin cofactor and the effect of sodium and potassium ions on its activity was determined. It was found that the thrombin-antithrombin complex formation facilitated with heparin was further accelerated by sodium or potassium chloride. The rate of thrombin inactivation showed a maximum between 0.1 and 0.2 M ion concentration in the presence of 0.012 units heparin per ml.

AB - A method was developed for partial purification of human antithrombin-heparin cofactor and the effect of sodium and potassium ions on its activity was determined. It was found that the thrombin-antithrombin complex formation facilitated with heparin was further accelerated by sodium or potassium chloride. The rate of thrombin inactivation showed a maximum between 0.1 and 0.2 M ion concentration in the presence of 0.012 units heparin per ml.

UR - http://www.scopus.com/inward/record.url?scp=0016776188&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016776188&partnerID=8YFLogxK

U2 - 10.1016/0049-3848(75)90189-9

DO - 10.1016/0049-3848(75)90189-9

M3 - Article

C2 - 51517

AN - SCOPUS:0016776188

VL - 7

SP - 305

EP - 313

JO - Thrombosis Research

JF - Thrombosis Research

SN - 0049-3848

IS - 2

ER -