Effect of sodium and potassium ions on the activity of human antithrombin-heparin cofactor

Raymund Machovich, György Blaskó, Ágnes Himer, Károly Szikla

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A method was developed for partial purification of human antithrombin-heparin cofactor and the effect of sodium and potassium ions on its activity was determined. It was found that the thrombin-antithrombin complex formation facilitated with heparin was further accelerated by sodium or potassium chloride. The rate of thrombin inactivation showed a maximum between 0.1 and 0.2 M ion concentration in the presence of 0.012 units heparin per ml.

Original languageEnglish
Pages (from-to)305-313
Number of pages9
JournalThrombosis research
Volume7
Issue number2
DOIs
Publication statusPublished - Aug 1975

ASJC Scopus subject areas

  • Hematology

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