Effect of single neonatal vitamin K1 treatment (imprinting) on the binding capacity of thymic glucocorticoid and uterine estrogen receptors of adolescent and adult rats

G. Csaba, Ágnes Inczefi-Gonda

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4 Citations (Scopus)

Abstract

Neonatal single treatment with vitamin K1 (50 μg/animal) significantly increased the density (B(max)) of thymic glucocorticoid receptors of the adolescent (6 weeks old) and uterine estrogen receptors of adult (10 weeks old) females. The same tendency was observed in the thymus of males and adult females, however without significance. Receptor affinity was (not significantly) influenced in the same direction. Considering that the steroid receptor imprinting effect of vitamins A and D as well as the imprinting- like effect of vitamin E was demonstrated earlier, the ability for neonatal steroid receptor imprinting of the whole lipid-soluble vitamin group is now justified.

Original languageEnglish
Pages (from-to)PL1-PL5
JournalLife Sciences
Volume65
Issue number1
DOIs
Publication statusPublished - May 28 1999

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Keywords

  • Hormonal imprinting
  • Lipid-soluble vitamins
  • Steroid receptors
  • Vitamin K

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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