Neonatal single treatment with vitamin K1 (50 μg/animal) significantly increased the density (B(max)) of thymic glucocorticoid receptors of the adolescent (6 weeks old) and uterine estrogen receptors of adult (10 weeks old) females. The same tendency was observed in the thymus of males and adult females, however without significance. Receptor affinity was (not significantly) influenced in the same direction. Considering that the steroid receptor imprinting effect of vitamins A and D as well as the imprinting- like effect of vitamin E was demonstrated earlier, the ability for neonatal steroid receptor imprinting of the whole lipid-soluble vitamin group is now justified.
- Hormonal imprinting
- Lipid-soluble vitamins
- Steroid receptors
- Vitamin K
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)