Egyszeri MSAID-kezelés hatása nehézel-lésekbo″l született borjak vegetatív ideg-rendszeri mu″ködest leíró szívmu″ködesi mutatóira és állással töltött idejére: Elözetes eredmények

Translated title of the contribution: Effect of single-dose NSAID treatment on cardiac autonomic activity and standing time of dairy calves born from dystocia Preliminary results

F. L. Kézér, L. Kovécs, D. Márton, J. Tözsér, O. Szenci

Research output: Contribution to journalArticle

Abstract

Background: Although non-steroidal anti-inflammatory drugs (NSAID) are increasingly used to reduce postpartum pain in dystocic cows and calves, the positive effects of NSAIDs on the well-being of the animals are still not proved. Objectives: In this study, the effects of a single-dose NSAID-treatment were investigated on well-being indicators (i.e., heart rate variability and standing time) in new-born calves (n = 24). Materials and Methods: The following parameters were investigated within the first 48 hours of life: (1) vitality scores (between 0 and 12) immediately after delivery and 2, and 24 hours thereafter; (2) time spent with standing during the first 2, 6,12, 24 and 48 hours of life, respectively; (3) sympathetic and parasympathetic indices of heart rate variability calculated for lying posture. Calves were allocated into groups as follows: Group 1: low vitality (between 2 and 7 scores, n = 8); Group 2: low vitality (between scores 2 and 7 + NSAID (single dose, 5 mg/ml meloxicam, 0,5 mg/kg live body weight, n - 8); Group 3: excellent vitality (between 10 and 12 scores, n = 8). Calves from Groups 1 and 2 were born from dystocia. Results and Discussion: Calves with excellent vitality spent more time in standing than calves in the other groups for all studied periods (p < 0.05 for all comparisons). Based on lower values of the root mean square of the successive R-R intervals and the high frequency component of heart rate variability calves from Group 1 exhibited lower vagal activity either than animals that received NSAID treatment or animals with excellent vitality following the first 12 hours. It indicates a greater postnatal stress load in calves with low vitality and suggest that NSAID treatment is successful in reducing stress/pain after a difficult calving in new-borns. Time spent in standing showed a strong positive linear correlation with vitality scores for both 2 (r = 0.67, p = 0.012) and 24 hours after delivery (r = 0.79, p = 0.01). Based on our results, time spent in standing may be an appropriate indicator of vitality in new-born calves. Single dose of NSAID decreases stress and pain caused by dystocia and increases time spent with standing in new-born calves during the first 24 hours of life.

Original languageHungarian
Pages (from-to)387-395
Number of pages9
JournalMagyar Allatorvosok Lapja
Volume139
Issue number7
Publication statusPublished - Jul 1 2017

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Dystocia
dairy calves
dystocia
nonsteroidal anti-inflammatory agents
drug therapy
Anti-Inflammatory Agents
calves
dosage
Pharmaceutical Preparations
Heart Rate
meloxicam
Pain
Therapeutics
heart rate
pain
Non-Steroidal Anti-Inflammatory Agents
Posture
Postpartum Period
animal well-being
Body Weight

ASJC Scopus subject areas

  • veterinary(all)

Cite this

@article{9028fb54de724cb79c6b8f0210fc8ca3,
title = "Egyszeri MSAID-kezel{\'e}s hat{\'a}sa neh{\'e}zel-l{\'e}sekbo″l sz{\"u}letett borjak vegetat{\'i}v ideg-rendszeri mu″k{\"o}dest le{\'i}r{\'o} sz{\'i}vmu″k{\"o}desi mutat{\'o}ira {\'e}s {\'a}ll{\'a}ssal t{\"o}lt{\"o}tt idej{\'e}re: El{\"o}zetes eredm{\'e}nyek",
abstract = "Background: Although non-steroidal anti-inflammatory drugs (NSAID) are increasingly used to reduce postpartum pain in dystocic cows and calves, the positive effects of NSAIDs on the well-being of the animals are still not proved. Objectives: In this study, the effects of a single-dose NSAID-treatment were investigated on well-being indicators (i.e., heart rate variability and standing time) in new-born calves (n = 24). Materials and Methods: The following parameters were investigated within the first 48 hours of life: (1) vitality scores (between 0 and 12) immediately after delivery and 2, and 24 hours thereafter; (2) time spent with standing during the first 2, 6,12, 24 and 48 hours of life, respectively; (3) sympathetic and parasympathetic indices of heart rate variability calculated for lying posture. Calves were allocated into groups as follows: Group 1: low vitality (between 2 and 7 scores, n = 8); Group 2: low vitality (between scores 2 and 7 + NSAID (single dose, 5 mg/ml meloxicam, 0,5 mg/kg live body weight, n - 8); Group 3: excellent vitality (between 10 and 12 scores, n = 8). Calves from Groups 1 and 2 were born from dystocia. Results and Discussion: Calves with excellent vitality spent more time in standing than calves in the other groups for all studied periods (p < 0.05 for all comparisons). Based on lower values of the root mean square of the successive R-R intervals and the high frequency component of heart rate variability calves from Group 1 exhibited lower vagal activity either than animals that received NSAID treatment or animals with excellent vitality following the first 12 hours. It indicates a greater postnatal stress load in calves with low vitality and suggest that NSAID treatment is successful in reducing stress/pain after a difficult calving in new-borns. Time spent in standing showed a strong positive linear correlation with vitality scores for both 2 (r = 0.67, p = 0.012) and 24 hours after delivery (r = 0.79, p = 0.01). Based on our results, time spent in standing may be an appropriate indicator of vitality in new-born calves. Single dose of NSAID decreases stress and pain caused by dystocia and increases time spent with standing in new-born calves during the first 24 hours of life.",
author = "K{\'e}z{\'e}r, {F. L.} and L. Kov{\'e}cs and D. M{\'a}rton and J. T{\"o}zs{\'e}r and O. Szenci",
year = "2017",
month = "7",
day = "1",
language = "Hungarian",
volume = "139",
pages = "387--395",
journal = "Magyar Allatorvosok Lapja",
issn = "0025-004X",
publisher = "Magyar Mezogazdasag Ltd",
number = "7",

}

TY - JOUR

T1 - Egyszeri MSAID-kezelés hatása nehézel-lésekbo″l született borjak vegetatív ideg-rendszeri mu″ködest leíró szívmu″ködesi mutatóira és állással töltött idejére

T2 - Elözetes eredmények

AU - Kézér, F. L.

AU - Kovécs, L.

AU - Márton, D.

AU - Tözsér, J.

AU - Szenci, O.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Background: Although non-steroidal anti-inflammatory drugs (NSAID) are increasingly used to reduce postpartum pain in dystocic cows and calves, the positive effects of NSAIDs on the well-being of the animals are still not proved. Objectives: In this study, the effects of a single-dose NSAID-treatment were investigated on well-being indicators (i.e., heart rate variability and standing time) in new-born calves (n = 24). Materials and Methods: The following parameters were investigated within the first 48 hours of life: (1) vitality scores (between 0 and 12) immediately after delivery and 2, and 24 hours thereafter; (2) time spent with standing during the first 2, 6,12, 24 and 48 hours of life, respectively; (3) sympathetic and parasympathetic indices of heart rate variability calculated for lying posture. Calves were allocated into groups as follows: Group 1: low vitality (between 2 and 7 scores, n = 8); Group 2: low vitality (between scores 2 and 7 + NSAID (single dose, 5 mg/ml meloxicam, 0,5 mg/kg live body weight, n - 8); Group 3: excellent vitality (between 10 and 12 scores, n = 8). Calves from Groups 1 and 2 were born from dystocia. Results and Discussion: Calves with excellent vitality spent more time in standing than calves in the other groups for all studied periods (p < 0.05 for all comparisons). Based on lower values of the root mean square of the successive R-R intervals and the high frequency component of heart rate variability calves from Group 1 exhibited lower vagal activity either than animals that received NSAID treatment or animals with excellent vitality following the first 12 hours. It indicates a greater postnatal stress load in calves with low vitality and suggest that NSAID treatment is successful in reducing stress/pain after a difficult calving in new-borns. Time spent in standing showed a strong positive linear correlation with vitality scores for both 2 (r = 0.67, p = 0.012) and 24 hours after delivery (r = 0.79, p = 0.01). Based on our results, time spent in standing may be an appropriate indicator of vitality in new-born calves. Single dose of NSAID decreases stress and pain caused by dystocia and increases time spent with standing in new-born calves during the first 24 hours of life.

AB - Background: Although non-steroidal anti-inflammatory drugs (NSAID) are increasingly used to reduce postpartum pain in dystocic cows and calves, the positive effects of NSAIDs on the well-being of the animals are still not proved. Objectives: In this study, the effects of a single-dose NSAID-treatment were investigated on well-being indicators (i.e., heart rate variability and standing time) in new-born calves (n = 24). Materials and Methods: The following parameters were investigated within the first 48 hours of life: (1) vitality scores (between 0 and 12) immediately after delivery and 2, and 24 hours thereafter; (2) time spent with standing during the first 2, 6,12, 24 and 48 hours of life, respectively; (3) sympathetic and parasympathetic indices of heart rate variability calculated for lying posture. Calves were allocated into groups as follows: Group 1: low vitality (between 2 and 7 scores, n = 8); Group 2: low vitality (between scores 2 and 7 + NSAID (single dose, 5 mg/ml meloxicam, 0,5 mg/kg live body weight, n - 8); Group 3: excellent vitality (between 10 and 12 scores, n = 8). Calves from Groups 1 and 2 were born from dystocia. Results and Discussion: Calves with excellent vitality spent more time in standing than calves in the other groups for all studied periods (p < 0.05 for all comparisons). Based on lower values of the root mean square of the successive R-R intervals and the high frequency component of heart rate variability calves from Group 1 exhibited lower vagal activity either than animals that received NSAID treatment or animals with excellent vitality following the first 12 hours. It indicates a greater postnatal stress load in calves with low vitality and suggest that NSAID treatment is successful in reducing stress/pain after a difficult calving in new-borns. Time spent in standing showed a strong positive linear correlation with vitality scores for both 2 (r = 0.67, p = 0.012) and 24 hours after delivery (r = 0.79, p = 0.01). Based on our results, time spent in standing may be an appropriate indicator of vitality in new-born calves. Single dose of NSAID decreases stress and pain caused by dystocia and increases time spent with standing in new-born calves during the first 24 hours of life.

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