Effect of Simultaneously Administered lopanoic Acid and Thyrotropin Releasing Hormone (TRH) on Thyroid Hormone Metabolism in Euthyroid Subjects

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Abstract

The cause of serum T4 elevation after iopanoic acid administration was searched in euthyroid subjects. 3 gr iopanoic acid was given per os to 9 healthy volunteers (group I), in other 5 volunteers a TRH test was performed prior to iopanoic acid administration (group II). In group I TSH, T4, FT4I and rT3 levels increased, in group II T3 and FT3I decreased, but no TSH, T4, FT4I increase was seen, obviously, because of the exhaustion of pituitary TSH content by TRH. On the ground of the findings T4 elevation caused by iopanoic acid is predominantly consequence of TSH release and not that of inhibited T4 conversion rate.

Original languageEnglish
Pages (from-to)365-368
Number of pages4
JournalExperimental and Clinical Endocrinology and Diabetes
Volume91
Issue number3
DOIs
Publication statusPublished - Aug 1988

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Keywords

  • Iopanoic acid
  • T metabolism
  • T-T conversion
  • TRH

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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