Effect of simultaneously administered iopanoic acid and thyrotropin releasing hormone (TRH) on thyroid hormone metabolism in euthyroid subjects

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Abstract

The cause ofserum T4 elevation after iopanoic acid administration was searched in euthyroid subjects, 3 gr iopanoic acid was given per os to 9 healthy volunteers (group I), in other 5 volunteers a TRH test was performed prior to iopanoic acid administrtion (group II). In group I TSH, T4, FT4I and rT3 levels increased, in group II T3 and FT3I decreased, but not TSH, T4, FT4I increase was seen, obviously, because of the exhaustion of pituitary TSH content by TSH. On the ground of the findings T4 elevation caused by iopanoic acid is predominantly consequence of TSH release and no that of inhibited T4 conversion rate.

Original languageEnglish
Pages (from-to)365-368
Number of pages4
JournalExperimental and Clinical Endocrinology
Volume91
Issue number3
Publication statusPublished - 1988

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Iopanoic Acid
Thyrotropin-Releasing Hormone
Thyroid Hormones
Volunteers
Healthy Volunteers

ASJC Scopus subject areas

  • Endocrinology

Cite this

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title = "Effect of simultaneously administered iopanoic acid and thyrotropin releasing hormone (TRH) on thyroid hormone metabolism in euthyroid subjects",
abstract = "The cause ofserum T4 elevation after iopanoic acid administration was searched in euthyroid subjects, 3 gr iopanoic acid was given per os to 9 healthy volunteers (group I), in other 5 volunteers a TRH test was performed prior to iopanoic acid administrtion (group II). In group I TSH, T4, FT4I and rT3 levels increased, in group II T3 and FT3I decreased, but not TSH, T4, FT4I increase was seen, obviously, because of the exhaustion of pituitary TSH content by TSH. On the ground of the findings T4 elevation caused by iopanoic acid is predominantly consequence of TSH release and no that of inhibited T4 conversion rate.",
author = "I. Szabolcs and Z. Kovacs and M. G{\'o}th and G. Szil{\'a}gyi",
year = "1988",
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journal = "Experimental and Clinical Endocrinology and Diabetes",
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T1 - Effect of simultaneously administered iopanoic acid and thyrotropin releasing hormone (TRH) on thyroid hormone metabolism in euthyroid subjects

AU - Szabolcs, I.

AU - Kovacs, Z.

AU - Góth, M.

AU - Szilágyi, G.

PY - 1988

Y1 - 1988

N2 - The cause ofserum T4 elevation after iopanoic acid administration was searched in euthyroid subjects, 3 gr iopanoic acid was given per os to 9 healthy volunteers (group I), in other 5 volunteers a TRH test was performed prior to iopanoic acid administrtion (group II). In group I TSH, T4, FT4I and rT3 levels increased, in group II T3 and FT3I decreased, but not TSH, T4, FT4I increase was seen, obviously, because of the exhaustion of pituitary TSH content by TSH. On the ground of the findings T4 elevation caused by iopanoic acid is predominantly consequence of TSH release and no that of inhibited T4 conversion rate.

AB - The cause ofserum T4 elevation after iopanoic acid administration was searched in euthyroid subjects, 3 gr iopanoic acid was given per os to 9 healthy volunteers (group I), in other 5 volunteers a TRH test was performed prior to iopanoic acid administrtion (group II). In group I TSH, T4, FT4I and rT3 levels increased, in group II T3 and FT3I decreased, but not TSH, T4, FT4I increase was seen, obviously, because of the exhaustion of pituitary TSH content by TSH. On the ground of the findings T4 elevation caused by iopanoic acid is predominantly consequence of TSH release and no that of inhibited T4 conversion rate.

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