Effect of silibinin and vitamin E on restoration of cellular immune response after partial hepatectomy

Monika É Horváth, R. González-Cabello, A. Blázovics, Marco Van der Looij, Irén Barta, G. Müzes, Péter Gergely, J. Fehér

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Our aim was to study the antioxidant and immunomodulatory effect of silibinin and vitamin E on the early postoperative course in rats that had undergone a partial hepatectomy (PHX). Male Wistar rats that were treated with silibinin (50 mg/b.w.kg i.p.) and/or vitamin E (500 mg/b.w.kg p.o.) were randomised to undergo 70% PHX. At 72 h after operation, Concanavalin A (Con-A) induced lymphocyte proliferation, and lipopolysaccharide (LPS) induced interleukin-1 (IL-1) mitogenicity and tumour necrosis factor-alpha (TNF-α) cytotoxicity were measured in the spleen. In addition, total free radical scavenger capacity of the liver was analysed. In PHX animals, Con-A induced lymphocyte proliferation was significantly decreased, and both LPS induced IL-1 and TNF-α activity were significantly increased as compared to Sham treated animals. Treatment with silibinin and vitamin E synergistically restored both lymphocyte proliferation (P

Original languageEnglish
Pages (from-to)227-232
Number of pages6
JournalJournal of Ethnopharmacology
Volume77
Issue number2-3
DOIs
Publication statusPublished - 2001

Fingerprint

Hepatectomy
Vitamin E
Cellular Immunity
Lymphocytes
Concanavalin A
Interleukin-1
Lipopolysaccharides
Tumor Necrosis Factor-alpha
Free Radical Scavengers
Wistar Rats
Spleen
Antioxidants
Liver
silybin

Keywords

  • Free radical
  • Immune response
  • Partial hepatectomy
  • Silibinin
  • Vitamin E

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of silibinin and vitamin E on restoration of cellular immune response after partial hepatectomy. / Horváth, Monika É; González-Cabello, R.; Blázovics, A.; Van der Looij, Marco; Barta, Irén; Müzes, G.; Gergely, Péter; Fehér, J.

In: Journal of Ethnopharmacology, Vol. 77, No. 2-3, 2001, p. 227-232.

Research output: Contribution to journalArticle

Horváth, Monika É ; González-Cabello, R. ; Blázovics, A. ; Van der Looij, Marco ; Barta, Irén ; Müzes, G. ; Gergely, Péter ; Fehér, J. / Effect of silibinin and vitamin E on restoration of cellular immune response after partial hepatectomy. In: Journal of Ethnopharmacology. 2001 ; Vol. 77, No. 2-3. pp. 227-232.
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