Effect of sexual steroids and androgen sterilization on avoidance and exploratory behaviour in the rat

G. Telegdy, A. Stark

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20 Citations (Scopus)

Abstract

The effect of estrogen, progesterone, testosterone, androgen sterilization and human chorionic gonadotrophin has been tested on acquisition, intertrial activity during acquisition, extinction, and intertrial activity during extinction of conditioned avoidance response and on exploratory activity. Estrogen in castrated female delayed extinction from the 8th day of extinction and increased intertrial activity during extinction. Estrogen treatment applied from extinction was ineffective. Progesterone treatment of castrated female rats applied from the first days of conditioning delayed extinction from the 12th day. If the treatment was begun at extinction this was delayed after the 8th day. Intertrial activity was also higher between the 8th and 15th day of extinction. Testosterone treatment of castrated male increased intertrial activity during acquisition. In the animals treated from extinction, a delay was observed from the 9th day and intertrial activity was increased simultaneously. In androgen sterilized female rats, extinction was facilitated. Human chorionic gonadotrophin treatment of intact female rats delayed the extinction. None of the experimental conditions was affecting the acquisition of conditioned avoidance response or exploratory activity.

Original languageEnglish
Pages (from-to)55-63
Number of pages9
JournalActa Physiologica Academiae Scientiarum Hungaricae
Volume43
Issue number1
Publication statusPublished - 1973

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Avoidance Learning
Exploratory Behavior
Androgens
Steroids
Estrogens
Chorionic Gonadotropin
Progesterone
Testosterone
Psychological Extinction

ASJC Scopus subject areas

  • Physiology

Cite this

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