Effect of sevoflurane on systemic and cerebral circulation, cerebral autoregulation and CO2 reactivity

Marianna Juhász, Levente Molnár, Béla Fülesdi, Tamás Végh, Dénes Páll, Csilla Molnár

Research output: Contribution to journalArticle

2 Citations (Scopus)


Background: Sevoflurane is one of the most frequently used inhaled anesthetics for general anesthesia. Previously it has been reported that at clinically used doses of sevoflurane, cerebral vasoreactivity is maintained. However, there are no data how sevoflurane influences systemic and cerebral circulation in parallel. The aim of our study was to assess systemic and cerebral hemodynamic changes as well as cerebral CO2-reactivity during sevoflurane anesthesia. Methods: Twenty nine patients undergoing general anesthesia were enrolled. Anesthesia was maintained with 1 MAC sevoflurane in 40% oxygen. Ventilatory settings (respiratory rate and tidal volume) were adjusted to reach and maintain 40, 35 and 30 mmHg EtCO2 for 5 min respectively. At the end of each period, transcranial Doppler and hemodynamic parameters using applanation tonometry were recorded. Results: Systemic mean arterial pressure significantly decreased during anesthetic induction and remained unchanged during the entire study period. Central aortic and peripherial pulse pressure and augmentation index as markers of arterial stiffness significantly increased during the anesthetic induction and remained stable at the time points when target CO2 levels were reached. Both cerebral autoregulation and cerebral CO2-reactivity was maintained at 1 MAC sevoflurane. Discussion: Cerebral autoregulation and CO2-reactivity is preserved at 1 MAC sevoflurane. Cerebrovascular effects of anesthetic compounds have to be assessed together with systemic circulatory effects. Trial registration: The study was registered at http://www.clinicaltrials.gov, identifier: NCT02054143, retrospectively registered. Date of registration: February 4, 2014.

Original languageEnglish
Article number109
JournalBMC anesthesiology
Issue number1
Publication statusPublished - Jun 19 2019


  • Applanation tonometry
  • CO-reactivity
  • Cerebral blood flow, cerebral autoregulation
  • Sevoflurane
  • Transcranial Doppler

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Fingerprint Dive into the research topics of 'Effect of sevoflurane on systemic and cerebral circulation, cerebral autoregulation and CO<sub>2</sub> reactivity'. Together they form a unique fingerprint.

  • Cite this