Effect of serotonin-acting agents on the serotonin content of immune cells. A peculiar observation

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3 Citations (Scopus)

Abstract

The effect of the tryptophan hydroxylase inhibitor, PCPA methylester, the serotonin reuptake inhibitor fluoxetine and MAO-A inhibitor clorgyline on the serotonin content of rat immune cells was studied, using labelled antibodies and flow cytometry. Each molecule significantly increased in males the serotonin concentration of peritoneal lymphocytes and the monocyte-macrophage-granulocyte group (mo-gran), however the agents were ineffective towards mast cells. In females fluoxetine and clorgyline increased the serotonin concentration in peritoneal lymphocytes and mo-gran. Fluoxetine also increased the serotonin level in mast cells. Thymus was absolutely resistant to the drugs in both genders. The results call attention (1) to the reverse effect of serotonin-acting agents on immune cells, (2) to the influence of the milieu where the cell is located and (3) the effect of gender.

Original languageEnglish
Pages (from-to)581-583
Number of pages3
JournalCell Biochemistry and Function
Volume25
Issue number5
DOIs
Publication statusPublished - Sep 2007

Fingerprint

Serotonin Agents
Fluoxetine
Serotonin
Clorgyline
Observation
Granulocytes
Mast Cells
Lymphocytes
Macrophages
Tryptophan Hydroxylase
Monoamine Oxidase Inhibitors
Monoamine Oxidase
Serotonin Uptake Inhibitors
Peritoneal Macrophages
Thymus
Flow cytometry
Thymus Gland
Monocytes
Flow Cytometry
Rats

Keywords

  • Enzyme inhibitors
  • Gender
  • Immunity
  • Reverse effect
  • Serotonin

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

Cite this

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abstract = "The effect of the tryptophan hydroxylase inhibitor, PCPA methylester, the serotonin reuptake inhibitor fluoxetine and MAO-A inhibitor clorgyline on the serotonin content of rat immune cells was studied, using labelled antibodies and flow cytometry. Each molecule significantly increased in males the serotonin concentration of peritoneal lymphocytes and the monocyte-macrophage-granulocyte group (mo-gran), however the agents were ineffective towards mast cells. In females fluoxetine and clorgyline increased the serotonin concentration in peritoneal lymphocytes and mo-gran. Fluoxetine also increased the serotonin level in mast cells. Thymus was absolutely resistant to the drugs in both genders. The results call attention (1) to the reverse effect of serotonin-acting agents on immune cells, (2) to the influence of the milieu where the cell is located and (3) the effect of gender.",
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