Effect of selective opiate antagonists on striatal acetylcholine and dopamine release

Norbert T. sandor, Balazs Lendvai, E. Vízi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

We investigated the effect of selective opiate antagonists on striatal acetylcholine (ACh) and dopamine (DA) release. The μ-receptor antagonist β-funaltrexamine (β-FNA), the δ-antagonist naltrindole (NTI), and the κ-antagonist norbinaltorphimine (nor-BNI) were used to selectively block different subtypes of opiate receptors. The experiments were carried out on isolated superfused striatal slices of rats, loaded with [3H]choline or [3H]dopamine. β-FNA and NTI significantly enhanced the electrical field stimulation-evoked release of ACh but only if the dopaminergic input had been impaired either by chemical denervation or D2 dopamine receptor blockade. By contrast, neither the selective nor nonselective antagonists had any modulatory effect on the release of dopamine. It is concluded, therefore, that the release of ACh is tonically controlled by endogenous opioid peptide(s) through the stimulation of μ- and δ-opiate receptors located on cholinergic axon terminals, in addition to the tonic control by DA.

Original languageEnglish
Pages (from-to)369-373
Number of pages5
JournalBrain Research Bulletin
Volume29
Issue number3-4
DOIs
Publication statusPublished - 1992

Fingerprint

Opiate Alkaloids
Corpus Striatum
naltrindole
Acetylcholine
Dopamine
Opioid Receptors
Opioid Peptides
Dopamine D2 Receptors
Presynaptic Terminals
Denervation
Choline
Cholinergic Agents
Electric Stimulation

Keywords

  • Endogenous opiate control μ-Receptor δ-Receptor ACh release DA release Rat striatum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Effect of selective opiate antagonists on striatal acetylcholine and dopamine release. / sandor, Norbert T.; Lendvai, Balazs; Vízi, E.

In: Brain Research Bulletin, Vol. 29, No. 3-4, 1992, p. 369-373.

Research output: Contribution to journalArticle

sandor, Norbert T. ; Lendvai, Balazs ; Vízi, E. / Effect of selective opiate antagonists on striatal acetylcholine and dopamine release. In: Brain Research Bulletin. 1992 ; Vol. 29, No. 3-4. pp. 369-373.
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