Effect of selected dimethylaminochalcones on some mitochondrial activities

Janka Vašková, Renáta Reisch, Ladislav Vaško, Martina Poškrobová, Ivan Kron, Juraj Guzy, P. Perjési

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Chalcones and their synthetic cyclic analogues have been shown to possess a full scale of biological activities in a variety of experimental systems. They were assessed to be mostly effective in defense against free radicals in the organism, but several compounds exhibited cytotoxic pro-oxidant activities. The respiratory response and antioxidant status in mitochondria were investigated upon addition of 4′-dimethylaminochalcone (1a) and its cyclic analogues, (E)-2-(4′-((CH3)2∈N)-benzylidene)-1-indanone (1b), -1-tetralone (1c), and -1-benzosuberone (1d). Selected structures were able to change the respiratory response of mitochondria and showed an ability to modify mitochondrial metabolic and redox efficiency, though they did not indicate redox reactivity towards glutathione in adduct-free incubations. The results of the study indicate that -chalcone and -tetralone derivatives cause suppression of reactive oxygen species affecting mitochondrial respiration by mild uncoupling. In addition, (E)-2-(4′-((CH3) 2∈N)-indanone (1b), and to a greater extent, -benzosuberone (1d), showed pro-oxidant effects, which partially explain their cytotoxicity.

Original languageEnglish
Pages (from-to)354-359
Number of pages6
JournalIn Vitro Cellular and Developmental Biology - Animal
Volume49
Issue number5
DOIs
Publication statusPublished - May 2013

Fingerprint

Tetralones
Reactive Oxygen Species
Oxidation-Reduction
Mitochondria
Chalcones
Chalcone
Free Radicals
Glutathione
Respiration
Antioxidants
dimethylaminochalcone
benzosuberone
indacrinone

Keywords

  • Antioxidant enzyme
  • Chalcone
  • Glutathione
  • Mitochondria
  • Respiration

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Effect of selected dimethylaminochalcones on some mitochondrial activities. / Vašková, Janka; Reisch, Renáta; Vaško, Ladislav; Poškrobová, Martina; Kron, Ivan; Guzy, Juraj; Perjési, P.

In: In Vitro Cellular and Developmental Biology - Animal, Vol. 49, No. 5, 05.2013, p. 354-359.

Research output: Contribution to journalArticle

Vašková, Janka ; Reisch, Renáta ; Vaško, Ladislav ; Poškrobová, Martina ; Kron, Ivan ; Guzy, Juraj ; Perjési, P. / Effect of selected dimethylaminochalcones on some mitochondrial activities. In: In Vitro Cellular and Developmental Biology - Animal. 2013 ; Vol. 49, No. 5. pp. 354-359.
@article{bfb999139af7480a8570321af5ce7e85,
title = "Effect of selected dimethylaminochalcones on some mitochondrial activities",
abstract = "Chalcones and their synthetic cyclic analogues have been shown to possess a full scale of biological activities in a variety of experimental systems. They were assessed to be mostly effective in defense against free radicals in the organism, but several compounds exhibited cytotoxic pro-oxidant activities. The respiratory response and antioxidant status in mitochondria were investigated upon addition of 4′-dimethylaminochalcone (1a) and its cyclic analogues, (E)-2-(4′-((CH3)2∈N)-benzylidene)-1-indanone (1b), -1-tetralone (1c), and -1-benzosuberone (1d). Selected structures were able to change the respiratory response of mitochondria and showed an ability to modify mitochondrial metabolic and redox efficiency, though they did not indicate redox reactivity towards glutathione in adduct-free incubations. The results of the study indicate that -chalcone and -tetralone derivatives cause suppression of reactive oxygen species affecting mitochondrial respiration by mild uncoupling. In addition, (E)-2-(4′-((CH3) 2∈N)-indanone (1b), and to a greater extent, -benzosuberone (1d), showed pro-oxidant effects, which partially explain their cytotoxicity.",
keywords = "Antioxidant enzyme, Chalcone, Glutathione, Mitochondria, Respiration",
author = "Janka Vaškov{\'a} and Ren{\'a}ta Reisch and Ladislav Vaško and Martina Poškrobov{\'a} and Ivan Kron and Juraj Guzy and P. Perj{\'e}si",
year = "2013",
month = "5",
doi = "10.1007/s11626-013-9600-x",
language = "English",
volume = "49",
pages = "354--359",
journal = "In Vitro Cellular and Developmental Biology - Animal",
issn = "1071-2690",
publisher = "Springer New York",
number = "5",

}

TY - JOUR

T1 - Effect of selected dimethylaminochalcones on some mitochondrial activities

AU - Vašková, Janka

AU - Reisch, Renáta

AU - Vaško, Ladislav

AU - Poškrobová, Martina

AU - Kron, Ivan

AU - Guzy, Juraj

AU - Perjési, P.

PY - 2013/5

Y1 - 2013/5

N2 - Chalcones and their synthetic cyclic analogues have been shown to possess a full scale of biological activities in a variety of experimental systems. They were assessed to be mostly effective in defense against free radicals in the organism, but several compounds exhibited cytotoxic pro-oxidant activities. The respiratory response and antioxidant status in mitochondria were investigated upon addition of 4′-dimethylaminochalcone (1a) and its cyclic analogues, (E)-2-(4′-((CH3)2∈N)-benzylidene)-1-indanone (1b), -1-tetralone (1c), and -1-benzosuberone (1d). Selected structures were able to change the respiratory response of mitochondria and showed an ability to modify mitochondrial metabolic and redox efficiency, though they did not indicate redox reactivity towards glutathione in adduct-free incubations. The results of the study indicate that -chalcone and -tetralone derivatives cause suppression of reactive oxygen species affecting mitochondrial respiration by mild uncoupling. In addition, (E)-2-(4′-((CH3) 2∈N)-indanone (1b), and to a greater extent, -benzosuberone (1d), showed pro-oxidant effects, which partially explain their cytotoxicity.

AB - Chalcones and their synthetic cyclic analogues have been shown to possess a full scale of biological activities in a variety of experimental systems. They were assessed to be mostly effective in defense against free radicals in the organism, but several compounds exhibited cytotoxic pro-oxidant activities. The respiratory response and antioxidant status in mitochondria were investigated upon addition of 4′-dimethylaminochalcone (1a) and its cyclic analogues, (E)-2-(4′-((CH3)2∈N)-benzylidene)-1-indanone (1b), -1-tetralone (1c), and -1-benzosuberone (1d). Selected structures were able to change the respiratory response of mitochondria and showed an ability to modify mitochondrial metabolic and redox efficiency, though they did not indicate redox reactivity towards glutathione in adduct-free incubations. The results of the study indicate that -chalcone and -tetralone derivatives cause suppression of reactive oxygen species affecting mitochondrial respiration by mild uncoupling. In addition, (E)-2-(4′-((CH3) 2∈N)-indanone (1b), and to a greater extent, -benzosuberone (1d), showed pro-oxidant effects, which partially explain their cytotoxicity.

KW - Antioxidant enzyme

KW - Chalcone

KW - Glutathione

KW - Mitochondria

KW - Respiration

UR - http://www.scopus.com/inward/record.url?scp=84878016740&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878016740&partnerID=8YFLogxK

U2 - 10.1007/s11626-013-9600-x

DO - 10.1007/s11626-013-9600-x

M3 - Article

VL - 49

SP - 354

EP - 359

JO - In Vitro Cellular and Developmental Biology - Animal

JF - In Vitro Cellular and Developmental Biology - Animal

SN - 1071-2690

IS - 5

ER -