Effect of salts on the hydrophobicity parameters of sulfosuccinic acid esters studied by reversed-phase thin-layer chromatography

Tibor Cserháti, Esther Forgács, Gergely Csiktusnádi Kiss, Joseph Augustin

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The lipophilicity and specific hydrophobic surface area of 11 sulfosuccinic acid esters have been determined by reversed phase thinlayer chromatography in ion free eluents and in eluents containing NaCl, KCl, MgCl2, and CaCl2. The strength and selectivity of the effect of salts were separated by use of the spectral mapping technique. Stepwise regression analysis was used to elucidate the relationship between the retention characteristics and the physicochemical parameters. Salts increased the retention of sulfosucrinic acid esters because of the salting-out effect and the suppression of the dissociation of the highly polar acidic group. They also influenced the retention selectivity, the effect being greater for the specific hydrophobic surface area then for the hydrophobicity. The retention of tile solutes was significantly dependent on the molar reflection and tile first and second coordinates of the two-dimensional nonlinear selectivity map depended on the calculated hydrophobicity and on the electron-withdrawing poffer of the substituent in the para position.

Original languageEnglish
Pages (from-to)441-446
Number of pages6
JournalJournal of Planar Chromatography - Modern TLC
Volume10
Issue number6
Publication statusPublished - Nov 1 1997

Keywords

  • Lipophilicity
  • Specific hydrophobic surface area
  • Spectral mapping technique
  • Sulfosuccinic acid esters

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Effect of salts on the hydrophobicity parameters of sulfosuccinic acid esters studied by reversed-phase thin-layer chromatography'. Together they form a unique fingerprint.

  • Cite this