Effect of retinoic acid treatment on cytogenetic remission of chronic myeloid leukaemia

Miklós Egyed, Balázs Kollár, G. Rumi, Éva Keller, János Vass, Sándorné Fekete

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The cytogenetic responses during the first chronic phase of 11 patients with chronic myeloid leukaemia (CML) treated with all-trans retinoic acid (ATRA) + interferon (IFN) were compared with those of 9 other CML patients treated with IFN alone. Metaphase and interphase cytogenetics and a semi-quantitative polymerase chain reaction were used to evaluate the cytogenetic responses. Two of the 11 patients in the ATRA + IFN group were withdrawn, one of them because of IFN intolerance, and the other because of non-compliance. Of the 9 remaining ATRA + IFN-treated patients 6 exhibited major cytogenetic responses, 3 of which were complete. Of the 9 patients treated with IFN alone, only 2 showed major cytogenetic responses. No severe adverse effects were observed. The preliminary results suggest that the ATRA + IFN combination may be superior in achieving cytogenetic remission in the first chronic phase of CML.

Original languageEnglish
Pages (from-to)84-89
Number of pages6
JournalActa Haematologica
Volume109
Issue number2
DOIs
Publication statusPublished - 2003

Fingerprint

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Tretinoin
Cytogenetics
Interferons
Therapeutics
Leukemia, Myeloid, Chronic Phase
Interphase
Metaphase
Polymerase Chain Reaction

Keywords

  • All-trans retinoic acid
  • Chronic myeloid leukaemia
  • EORTC-LG
  • WHO-ECOG

ASJC Scopus subject areas

  • Hematology

Cite this

Effect of retinoic acid treatment on cytogenetic remission of chronic myeloid leukaemia. / Egyed, Miklós; Kollár, Balázs; Rumi, G.; Keller, Éva; Vass, János; Fekete, Sándorné.

In: Acta Haematologica, Vol. 109, No. 2, 2003, p. 84-89.

Research output: Contribution to journalArticle

Egyed, Miklós ; Kollár, Balázs ; Rumi, G. ; Keller, Éva ; Vass, János ; Fekete, Sándorné. / Effect of retinoic acid treatment on cytogenetic remission of chronic myeloid leukaemia. In: Acta Haematologica. 2003 ; Vol. 109, No. 2. pp. 84-89.
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