Effect of retinoic acid treatment on cytogenetic remission of chronic myeloid leukaemia

Miklós Egyed, Balázs Kollár, György Rumi, Éva Keller, János Vass, Sándorné Fekete

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The cytogenetic responses during the first chronic phase of 11 patients with chronic myeloid leukaemia (CML) treated with all-trans retinoic acid (ATRA) + interferon (IFN) were compared with those of 9 other CML patients treated with IFN alone. Metaphase and interphase cytogenetics and a semi-quantitative polymerase chain reaction were used to evaluate the cytogenetic responses. Two of the 11 patients in the ATRA + IFN group were withdrawn, one of them because of IFN intolerance, and the other because of non-compliance. Of the 9 remaining ATRA + IFN-treated patients 6 exhibited major cytogenetic responses, 3 of which were complete. Of the 9 patients treated with IFN alone, only 2 showed major cytogenetic responses. No severe adverse effects were observed. The preliminary results suggest that the ATRA + IFN combination may be superior in achieving cytogenetic remission in the first chronic phase of CML.

Original languageEnglish
Pages (from-to)84-89
Number of pages6
JournalActa Haematologica
Issue number2
Publication statusPublished - Mar 20 2003


  • All-trans retinoic acid
  • Chronic myeloid leukaemia

ASJC Scopus subject areas

  • Hematology

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