Retinsav hatása a citogenetikai remisszióra krónikus myeloid leukaemia interferonnal kezelt elsó krónikus fázisában.

Translated title of the contribution: Effect of retinoic acid on the cytogenetic remission in the first chronic phase of chronic myeloid leukemia treated with interferon

M. Egyed, Z. Mihályfalvi, B. Kollár, G. Rumi, E. Keller, J. Vass, S. Fekete

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cytogenetic responses of 11 chronic myeloid leukemic (CML) patients during the first chronic phase, treated with the combination of all-trans retinoic acid (ATRA) + interferon (IFN) were compared to 9 other CML patients of phase one, treated with interferon monotherapy. Metaphase and interphase cytogenetics and a semiquantitative polymerase chain reaction (PCR) were used to evaluate the cytogenetic responses. Two of the 11 patients in the ATRA + interferon treated group were withdrawn, one of them because of interferon intolerance, and the other because of compliance failure. Among the 9 ATRA + interferon treated patients 6 major cytogenetic responses could be detected and 3 of them were complete. Of the 9 patients treated with IFN monotherapy only 2 major cytogenetic responses could be registered. No severe adverse effects were observed. The first results suggest that the ATRA + interferon combination may be superior in achieving cytogenetic remission in the first chronic phase of CML.

Translated title of the contributionEffect of retinoic acid on the cytogenetic remission in the first chronic phase of chronic myeloid leukemia treated with interferon
Original languageHungarian
Pages (from-to)2421-2425
Number of pages5
JournalOrvosi hetilap
Volume142
Issue number44
Publication statusPublished - Nov 4 2001

ASJC Scopus subject areas

  • Medicine(all)

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    Egyed, M., Mihályfalvi, Z., Kollár, B., Rumi, G., Keller, E., Vass, J., & Fekete, S. (2001). Retinsav hatása a citogenetikai remisszióra krónikus myeloid leukaemia interferonnal kezelt elsó krónikus fázisában. Orvosi hetilap, 142(44), 2421-2425.