Effect of resiniferatoxin on stimulated gastric acid secretory responses in the rat

O. M.E. Abdel-Salam, J. Szolcsányi, Gy Mózsik

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The effect of the capsaicin analogue 'resiniferatoxin' (RTX) was studied on basal and stimulated gastric acid secretory responses following sc bethanechol (1.5 mg/kg), sc pentagastrin (50 μg/kg) and sc histamine (0.5 and 2.5 mg/kg) in the 1-h pylorusligated plus saline (2 ml ig)-treated rats. Resiniferatoxin applied intragastrically in doses of 0.6 and 1 μg/kg at time of pylorus-ligation and administration of the above secretagogues reduced acid secretory respones to bethanechol by 18.3 and 26.4%, to 0.5 mg/kg histamine by 39.9 and 44.6%, to 2.5 mg/kg histamine by 21.3 and 40.8% and to pentagastrin by 10.2 and 30.9% respectively. A single sc injection of 0.4 μg/kg of RTX abolished basal secretion in pylorus ligated rats (which did not receive ig saline). Our results indicate that locally applied RTX is capable of inhibiting basal secretory responses and modifying gastric acid responses stimulated with histamine, bethanechol or pentagastrin in the rat.

Original languageEnglish
Pages (from-to)353-358
Number of pages6
JournalJournal of Physiology - Paris
Volume88
Issue number6
DOIs
Publication statusPublished - 1994

Keywords

  • bethanechol
  • gastric acid secretion
  • histamine
  • pentagastrin
  • resiniferatoxin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)

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