Effect of released lymphocyte proteins on human lymphocytes in vitro

M. T. Szabo, A. Hrabák, F. Antoni

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3 Citations (Scopus)

Abstract

The effect on lymphocytes and Hep2 target cells of proteins obtained from the medium of human lymphocytes incubated for short times was studied. The supernatants were precipitated and fractionated with ammonium sulfate in three steps. Two protein fractions were found to inhibit protein synthesis in target cells and to increase in vitro release of chromium from prelabelled lymphocytes. The proteins studied may be related to lymphotoxin produced by mitogen-activated lymphocytes. It is assumed that in vitro interactions for short times between different types of lymphocytes may cause the release of proteins. The same proteins play probably a part in the in vivo regulation of the metabolic activity of lymphocytes.

Original languageEnglish
Pages (from-to)13-21
Number of pages9
JournalActa Biochimica et Biophysica Academiae Scientiarum Hungaricae
Volume13
Issue number1-2
Publication statusPublished - 1978

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Lymphocytes
Proteins
Lymphotoxin-alpha
Ammonium Sulfate
Chromium
Mitogens
In Vitro Techniques

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effect of released lymphocyte proteins on human lymphocytes in vitro. / Szabo, M. T.; Hrabák, A.; Antoni, F.

In: Acta Biochimica et Biophysica Academiae Scientiarum Hungaricae, Vol. 13, No. 1-2, 1978, p. 13-21.

Research output: Contribution to journalArticle

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