Effect of quinacrine treatment on the activity of acid hydrolases (phosphatase, N-acetyl-β-glucosaminidase, glucosidase, galactosidase and esterase) in Tetrahymena

P. Kovács, G. Csaba

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Abstract

The effect of phospholipase A2 (PLA2) inhibitor, quinacrine, on the activity of hydrolytic enzymes in Tetrahymena pyriformis homogenate, was investigated. The activity of all of the enzymes studied (acid phosphatase, N-acetyl-β-glusosaminidase, glucosidase, galactosidase and esterase) was significantly reduced in the presence of quinacrine. Since there are no data on the inhibitory effect of PLA2 and PLA2 influenced metabolic pathways to the hydrolytic enzymes, the direct effect of quinacrine on the hydrolytic enzymes (of Tetrahymena) can be supposed. This is supported by the fact that the other PLA2 inhibitor, 4-bromophenacyl bromide, did not influence phosphatase activity.

Original languageEnglish
Pages (from-to)287-290
Number of pages4
JournalCell biochemistry and function
Volume19
Issue number4
DOIs
Publication statusPublished - Dec 10 2001

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Keywords

  • 4-bromophenacyl bromide
  • Hydrolytic enzymes
  • PLA2 inhibitors
  • Quinacrine
  • Tetrahymena pyriformis

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Cell Biology

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