Effect of prostaglandins on hypothalamic-pituitary-testicular function in vitro

I. Vermes, J. Dohanics, G. Telegdy

Research output: Contribution to journalArticle

Abstract

The effect of prostaglandins (PG) A1, E1, E2 and F[2α] in the concentration range of 10-7-10-4 M were studied in vitro on rat hypothalamic tissue, collagenase-digested isolated anterior pituitary cell and a Leydig cell suspension system by measuring the testosterone production of incubated Leydig cells. PGs did not change the testosterone production and the hCG sensitivity of the Leydig cells, nor the LH secretion and the LHRH sensitivity of the anterior pituitary cells. PGE2 at concentrations of 10-6, 10-5 and 10-4 M significantly increased the hypothalamic tissue-induced pituitary-testicular activation, and this stimulatory effect of PGE2 was dose dependent. PGA1, PGE1, and PGF[2α] did not alter hypothalamic LHRh release measured in vitro. The results suggest that PGE2 has a direct stimulatory effect on hypothalamic LHRH release.

Original languageEnglish
Pages (from-to)401-404
Number of pages4
JournalActa Physiologica Academiae Scientiarum Hungaricae
Volume54
Issue number4
Publication statusPublished - 1979

Fingerprint

Leydig Cells
Dinoprostone
Prostaglandins
Alprostadil
Prostaglandins F
Gonadotropin-Releasing Hormone
Testosterone
Collagenases
Suspensions
In Vitro Techniques
prostaglandin A1

ASJC Scopus subject areas

  • Physiology

Cite this

Effect of prostaglandins on hypothalamic-pituitary-testicular function in vitro. / Vermes, I.; Dohanics, J.; Telegdy, G.

In: Acta Physiologica Academiae Scientiarum Hungaricae, Vol. 54, No. 4, 1979, p. 401-404.

Research output: Contribution to journalArticle

@article{ce74424e429b456da055ae4e309d4167,
title = "Effect of prostaglandins on hypothalamic-pituitary-testicular function in vitro",
abstract = "The effect of prostaglandins (PG) A1, E1, E2 and F[2α] in the concentration range of 10-7-10-4 M were studied in vitro on rat hypothalamic tissue, collagenase-digested isolated anterior pituitary cell and a Leydig cell suspension system by measuring the testosterone production of incubated Leydig cells. PGs did not change the testosterone production and the hCG sensitivity of the Leydig cells, nor the LH secretion and the LHRH sensitivity of the anterior pituitary cells. PGE2 at concentrations of 10-6, 10-5 and 10-4 M significantly increased the hypothalamic tissue-induced pituitary-testicular activation, and this stimulatory effect of PGE2 was dose dependent. PGA1, PGE1, and PGF[2α] did not alter hypothalamic LHRh release measured in vitro. The results suggest that PGE2 has a direct stimulatory effect on hypothalamic LHRH release.",
author = "I. Vermes and J. Dohanics and G. Telegdy",
year = "1979",
language = "English",
volume = "54",
pages = "401--404",
journal = "Physiology International",
issn = "2498-602X",
publisher = "Akademiai Kiado",
number = "4",

}

TY - JOUR

T1 - Effect of prostaglandins on hypothalamic-pituitary-testicular function in vitro

AU - Vermes, I.

AU - Dohanics, J.

AU - Telegdy, G.

PY - 1979

Y1 - 1979

N2 - The effect of prostaglandins (PG) A1, E1, E2 and F[2α] in the concentration range of 10-7-10-4 M were studied in vitro on rat hypothalamic tissue, collagenase-digested isolated anterior pituitary cell and a Leydig cell suspension system by measuring the testosterone production of incubated Leydig cells. PGs did not change the testosterone production and the hCG sensitivity of the Leydig cells, nor the LH secretion and the LHRH sensitivity of the anterior pituitary cells. PGE2 at concentrations of 10-6, 10-5 and 10-4 M significantly increased the hypothalamic tissue-induced pituitary-testicular activation, and this stimulatory effect of PGE2 was dose dependent. PGA1, PGE1, and PGF[2α] did not alter hypothalamic LHRh release measured in vitro. The results suggest that PGE2 has a direct stimulatory effect on hypothalamic LHRH release.

AB - The effect of prostaglandins (PG) A1, E1, E2 and F[2α] in the concentration range of 10-7-10-4 M were studied in vitro on rat hypothalamic tissue, collagenase-digested isolated anterior pituitary cell and a Leydig cell suspension system by measuring the testosterone production of incubated Leydig cells. PGs did not change the testosterone production and the hCG sensitivity of the Leydig cells, nor the LH secretion and the LHRH sensitivity of the anterior pituitary cells. PGE2 at concentrations of 10-6, 10-5 and 10-4 M significantly increased the hypothalamic tissue-induced pituitary-testicular activation, and this stimulatory effect of PGE2 was dose dependent. PGA1, PGE1, and PGF[2α] did not alter hypothalamic LHRh release measured in vitro. The results suggest that PGE2 has a direct stimulatory effect on hypothalamic LHRH release.

UR - http://www.scopus.com/inward/record.url?scp=0018606641&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018606641&partnerID=8YFLogxK

M3 - Article

C2 - 398665

AN - SCOPUS:0018606641

VL - 54

SP - 401

EP - 404

JO - Physiology International

JF - Physiology International

SN - 2498-602X

IS - 4

ER -