Effect of prostaglandins and drotaverine on ADP induced platelet aggregation

H. Losonczy, I. Nagy, Z. Gregus

Research output: Contribution to journalArticle

Abstract

Prostaglandins E1 and E2 have been studied for their effect on platelet aggregation in vitro. PGE1 proved a highly potent, PGE2 a slightly less potent inhibitor of platelet aggregation. The two prostaglandins were also studied in combination with drotaverine the inhibitory activity of which against ADP induced platelet aggregation had been found to function at high concentrations only. Both combinations revealed a potentiating synergism in vitro resulting in a total reversal of platelet aggregation at concentrations which are ineffective when the drugs are applied by themselves.

Original languageEnglish
Pages (from-to)157-163
Number of pages7
JournalActa Medica Academiae Scientiarum Hungaricae
Volume31
Issue number3-4
Publication statusPublished - 1974

Fingerprint

Platelet Aggregation
Adenosine Diphosphate
Prostaglandins
Alprostadil
Dinoprostone
Platelet Aggregation Inhibitors
Pharmaceutical Preparations
drotaverin
In Vitro Techniques

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effect of prostaglandins and drotaverine on ADP induced platelet aggregation. / Losonczy, H.; Nagy, I.; Gregus, Z.

In: Acta Medica Academiae Scientiarum Hungaricae, Vol. 31, No. 3-4, 1974, p. 157-163.

Research output: Contribution to journalArticle

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