Effect of prostaglandin I2 on platelet adhesion

László Fésüs, Jolán Hársfalvi, Eszter Kovács, László Muszbek, István Stadler

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Abstract

The adherence of platelets to collagen fibrils was not affected by prostaglandin I2 (PGI2) applied in a wide concentration range (0.1-100 ng/ml). The retention of platelets on glass beads which includes adhesion as well as subsequent clumping of platelets was, however, greatly reduced at PGI2 concentrations higher than 0.5 ng/ml. The results suggest that PGI2 even at high concentration does not interfere with the primary process of platelet adhesion, i.e., with the formation of a monocellular platelet layer on collagen fibrils and artificial surfaces, but it inhibits clumping of further platelets to this layer and prevents subsequent platelet thrombus formation.

Original languageEnglish
Pages (from-to)53-54
Number of pages2
JournalBiomaterials
Volume2
Issue number1
DOIs
Publication statusPublished - Jan 1981

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ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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