Effect of prostaglandin E1 and indomethacin on responses of longitudinal muscle of guinea-pig ileum to cholecystokinin

János Zséli, Tamás L. Török, Szilveszter E. Vizi, József Knoll

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effect of prostaglandin E1 (PGE1) and indomethacin (IND) cholecystokinin (CCK)-induced contractions of guinea-pig isolated ileum longitudinal muscle were studied. PGE1 (2.8-28 nM) consistently and dose dependently increased the contractions evoked by CCK (indirect muscle stimulation) or by ACh. IND (2.7μM) decreased the contractions to both compounds and this was reversed with 2.8-7 nM PGE1. Pretreatment of the preparations with phentolamine (2.6μM) or pretreatment of the animals with reserpine (2 mg/kg i.p. 24 h before killing) did not affect PGE1 potentiation or IND inhibition of CCK-induced contractions. The results indicated that PGE1 potentiated CCK-induced contractions of the longitudinal muscle of guinea-pig ileum by increasing the response to released ACh. Experiments with IND suggested that endogenous PGs may modulate the effect of CCK or related gastrointestinal hormones.

Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalEuropean Journal of Pharmacology
Volume56
Issue number1-2
DOIs
Publication statusPublished - Jun 1 1979

Keywords

  • Cholecystokinin
  • Ileal longitudinal muscle
  • Indomethacin
  • Prostaglandin E

ASJC Scopus subject areas

  • Pharmacology

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