Effect of prostacyclin on cardiac transmembrane currents.

R. Markó, K. Kelemen, V. Kecskeméti, J. Knoll

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The relatively stable sodium salt of prostacyclin, PGI2-Na, kindly supplied by Chinoin Works (Budapest), was found to induce a dose-dependent increase in the inward-going membrane current of the sinoauricular fiber of the frog. Threshold concentration was 0.05 microgram/ml, and maximal effect was reached at a concentration of about 0.1 microgram/ml. Supramaximal concentrations of PGI2-Na evoked a maximal response, in contrast to primary prostaglandins, the dose-response curves of which decline at supramaximal values. The stimulatory effect of PGI2-Na was confined to the fast component of the inward current and was also readily demonstrable in the presence of Mn ions, i.e., with the slow channel blocked. The PGI2-Na was, however, ineffective in sodium-free medium (choline Ringer) or in the presence of 1 microgram/ml tetrodotoxin. Endogenous prostacyclin is likely to contribute to the regulation of cardiac cell membrane processes.

Original languageEnglish
Pages (from-to)107-113
Number of pages7
JournalAdvances in myocardiology
Volume3
Publication statusPublished - 1982

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Epoprostenol
Sodium
Tetrodotoxin
Choline
Anura
Prostaglandins
Salts
Cell Membrane
Ions
Membranes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effect of prostacyclin on cardiac transmembrane currents. / Markó, R.; Kelemen, K.; Kecskeméti, V.; Knoll, J.

In: Advances in myocardiology, Vol. 3, 1982, p. 107-113.

Research output: Contribution to journalArticle

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N2 - The relatively stable sodium salt of prostacyclin, PGI2-Na, kindly supplied by Chinoin Works (Budapest), was found to induce a dose-dependent increase in the inward-going membrane current of the sinoauricular fiber of the frog. Threshold concentration was 0.05 microgram/ml, and maximal effect was reached at a concentration of about 0.1 microgram/ml. Supramaximal concentrations of PGI2-Na evoked a maximal response, in contrast to primary prostaglandins, the dose-response curves of which decline at supramaximal values. The stimulatory effect of PGI2-Na was confined to the fast component of the inward current and was also readily demonstrable in the presence of Mn ions, i.e., with the slow channel blocked. The PGI2-Na was, however, ineffective in sodium-free medium (choline Ringer) or in the presence of 1 microgram/ml tetrodotoxin. Endogenous prostacyclin is likely to contribute to the regulation of cardiac cell membrane processes.

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