Effect of prenatal allylestrenol treatment (hormonal imprinting) on the serum testosterone and progesterone level in adult rats

Erna Pap, G. Csaba

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

1. 1. Female rats were treated with allylestrenol on the 15th, 17th and 19th days of their pregnancy. 2. 2. Serum testosterone and progesterone level of their three months old offspring were higher than control in males and females, respectively. 3. 3. Serum progesterone levels of females, treated both prenatally and in adulthood, does not differ from control values. Serum testosterone level of males, treated prenatally and in adulthood, is lower than control. 4. 4. One single allylestrenol treatment in adulthood does not make changes in testosterone concentration in males, but progesterone level is elevated in females. 5. 5. Our experiments draw attention to the dangers of prenatal allylestrenol treatments (administered in case of endangered pregnancies) which may have long lasting effects on sexual steroid hormone levels.

Original languageEnglish
Pages (from-to)365-367
Number of pages3
JournalGeneral Pharmacology
Volume26
Issue number2
DOIs
Publication statusPublished - 1995

Fingerprint

Allylestrenol
Progesterone
Testosterone
Serum
Pregnancy
Steroids
Hormones

Keywords

  • allylestrenol
  • Hormonal imprinting
  • progesterone
  • testosterone

ASJC Scopus subject areas

  • Pharmacology

Cite this

@article{f74b8b65d0c147f3bca88c54f973b009,
title = "Effect of prenatal allylestrenol treatment (hormonal imprinting) on the serum testosterone and progesterone level in adult rats",
abstract = "1. 1. Female rats were treated with allylestrenol on the 15th, 17th and 19th days of their pregnancy. 2. 2. Serum testosterone and progesterone level of their three months old offspring were higher than control in males and females, respectively. 3. 3. Serum progesterone levels of females, treated both prenatally and in adulthood, does not differ from control values. Serum testosterone level of males, treated prenatally and in adulthood, is lower than control. 4. 4. One single allylestrenol treatment in adulthood does not make changes in testosterone concentration in males, but progesterone level is elevated in females. 5. 5. Our experiments draw attention to the dangers of prenatal allylestrenol treatments (administered in case of endangered pregnancies) which may have long lasting effects on sexual steroid hormone levels.",
keywords = "allylestrenol, Hormonal imprinting, progesterone, testosterone",
author = "Erna Pap and G. Csaba",
year = "1995",
doi = "10.1016/0306-3623(94)00188-S",
language = "English",
volume = "26",
pages = "365--367",
journal = "Vascular Pharmacology",
issn = "1537-1891",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Effect of prenatal allylestrenol treatment (hormonal imprinting) on the serum testosterone and progesterone level in adult rats

AU - Pap, Erna

AU - Csaba, G.

PY - 1995

Y1 - 1995

N2 - 1. 1. Female rats were treated with allylestrenol on the 15th, 17th and 19th days of their pregnancy. 2. 2. Serum testosterone and progesterone level of their three months old offspring were higher than control in males and females, respectively. 3. 3. Serum progesterone levels of females, treated both prenatally and in adulthood, does not differ from control values. Serum testosterone level of males, treated prenatally and in adulthood, is lower than control. 4. 4. One single allylestrenol treatment in adulthood does not make changes in testosterone concentration in males, but progesterone level is elevated in females. 5. 5. Our experiments draw attention to the dangers of prenatal allylestrenol treatments (administered in case of endangered pregnancies) which may have long lasting effects on sexual steroid hormone levels.

AB - 1. 1. Female rats were treated with allylestrenol on the 15th, 17th and 19th days of their pregnancy. 2. 2. Serum testosterone and progesterone level of their three months old offspring were higher than control in males and females, respectively. 3. 3. Serum progesterone levels of females, treated both prenatally and in adulthood, does not differ from control values. Serum testosterone level of males, treated prenatally and in adulthood, is lower than control. 4. 4. One single allylestrenol treatment in adulthood does not make changes in testosterone concentration in males, but progesterone level is elevated in females. 5. 5. Our experiments draw attention to the dangers of prenatal allylestrenol treatments (administered in case of endangered pregnancies) which may have long lasting effects on sexual steroid hormone levels.

KW - allylestrenol

KW - Hormonal imprinting

KW - progesterone

KW - testosterone

UR - http://www.scopus.com/inward/record.url?scp=0028911578&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028911578&partnerID=8YFLogxK

U2 - 10.1016/0306-3623(94)00188-S

DO - 10.1016/0306-3623(94)00188-S

M3 - Article

C2 - 7590089

AN - SCOPUS:0028911578

VL - 26

SP - 365

EP - 367

JO - Vascular Pharmacology

JF - Vascular Pharmacology

SN - 1537-1891

IS - 2

ER -