Effect of prazosin and oxprenolol on plasma renin activity and blood pressure in patients with essential hypertension

C. Farsang, I. Juhasz, J. Kapocsi, L. Vajda, B. Székács

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

48 patients with normal-renin essential hypertension were treated with prazosin alone or in combination with oxprenolol. 1 h after a single dose of 2 mg prazosin tachycardia and a decrease in blood pressure developed. Renin activity in the peripheral plasma (PRA) increased from 1.04 ± 0.15 to 2.64 ± 0.20 ng AgT/ml/h. A 3-day treatment with 2 mg t.i.d. prazosin of 11 patients caused no further decrease in blood pressure, while PRA returned to the baseline level. Treatment for 3 days with 2 mg prazosin t.i.d. and 40 mg oxprenolol t.i.d. of 37 patients further decreased blood pressure as well as PRA. The increase in PRA after a single dose of prazosin could be related to the enhanced sympathetic activity. The decreased PRA after prazosin + oxprenolol therapy may be one of the factors responsible for the greater antihypertensive response to the combined therapy.

Original languageEnglish
Pages (from-to)164-171
Number of pages8
JournalCardiology (Switzerland)
Volume67
Issue number3
Publication statusPublished - 1981

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Oxprenolol
Prazosin
Renin
Blood Pressure
Therapeutics
Tachycardia
Antihypertensive Agents
Essential Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effect of prazosin and oxprenolol on plasma renin activity and blood pressure in patients with essential hypertension. / Farsang, C.; Juhasz, I.; Kapocsi, J.; Vajda, L.; Székács, B.

In: Cardiology (Switzerland), Vol. 67, No. 3, 1981, p. 164-171.

Research output: Contribution to journalArticle

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AU - Székács, B.

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AB - 48 patients with normal-renin essential hypertension were treated with prazosin alone or in combination with oxprenolol. 1 h after a single dose of 2 mg prazosin tachycardia and a decrease in blood pressure developed. Renin activity in the peripheral plasma (PRA) increased from 1.04 ± 0.15 to 2.64 ± 0.20 ng AgT/ml/h. A 3-day treatment with 2 mg t.i.d. prazosin of 11 patients caused no further decrease in blood pressure, while PRA returned to the baseline level. Treatment for 3 days with 2 mg prazosin t.i.d. and 40 mg oxprenolol t.i.d. of 37 patients further decreased blood pressure as well as PRA. The increase in PRA after a single dose of prazosin could be related to the enhanced sympathetic activity. The decreased PRA after prazosin + oxprenolol therapy may be one of the factors responsible for the greater antihypertensive response to the combined therapy.

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