Effect of Potassium on the Release of [3H]Noradrenaline from Rabbit and Human Pulmonary Artery

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Abstract

Abstract: The release of [3H]noradrenaline ([3H]NA) from rabbit and human isolated pulmonary artery has been measured. Removal of external potassium ions enhanced both the resting and stimulated release of [3H]NA from the strips. On adding K+ to tissues which had been suspended in K+ ‐free Krebs solution, the release of [3H]NA was reduced in both stimulated and unstimulated tissues. Selective inhibition of presynaptic α2adrenoceptors by yohimbine significantly potentiated the release of [3H]NA evoked by stimulation in K+ ‐free solution. The presynaptic inhibitory effect of NA was much less pronounced when the release was enhanced by the removal of external K+. Since the activity of Na,K‐ATPase may be affected by removing K+ or by adding it to tissue previously kept in K+‐free solution, the results may indicate involvement of the sodium pump in NA release.

Original languageEnglish
Pages (from-to)670-676
Number of pages7
JournalJournal of neurochemistry
Volume42
Issue number3
DOIs
Publication statusPublished - Mar 1984

Keywords

  • Negative feedback
  • Potassium
  • Rabbit and human pulmonary artery
  • [H]Noradrenaline release

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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