Effect of potassium loading in vivo on steroid production in vitro by the quartered adrenal and the adrenal capsule of the rat

J. Sólyom, J. Regoly Merei, A. Korner

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Abstract

Chronic oral potassium loading increases the amount of aldosterone and decreases that of corticosterone produced in vitro by quartered whole adrenal of the rat. Since the amount of corticosterone produced by the decapsulated adrenal remains unchanged, whereas that produced by the capsular adrenal is decreased, the change in corticosterone production seems to be due to a change in the activity of the glomerulosa cells and is attributed to an enhanced 18 hydroxylase activity. Sodium repletion induced simultaneously with potassium loading had the same effect as oral potassium by itself.

Original languageEnglish
Pages (from-to)19-26
Number of pages8
JournalActa Physiologica Academiae Scientiarum Hungaricae
Volume43
Issue number1
Publication statusPublished - 1973

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Corticosterone
Capsules
Potassium
Steroids
Mixed Function Oxygenases
Aldosterone
Sodium
In Vitro Techniques

ASJC Scopus subject areas

  • Physiology

Cite this

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