Hogyan befolyásolják a posztoperatív komplikációk a késoi recidívák és a távoli metastasisok kialakulását colorectalis carcinomák elektív, kuratív resectióját követoen?

Translated title of the contribution: [Effect of postoperative complications on late recurrence and distant metastasis in patients previously treated with elective, curative resection of colorectal carcinoma].

Péter Zsoldos, László Hegedüs, Akos Issekutz, A. Oláh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The aim of the present study is to investigate whether severe postoperative complications following elective colorectal surgery increase local recurrence or distant metastasis rate. 332 patients underwent elective, curative colorectal carcinoma resection in the period between 01.01.2000 and 31.12.2004. Postoperative complications were classified according to the modified Clavien Scale. Complications occurring up to postoperative day 30 were recorded. All complications were analyzed but the most severe one was considered for each patient and included in further analysis. Patients were followed up until 31.12.2009. Univariate and multivariate statistical analyses were performed. The mean age of patients was 64 years, 187 (56%) were male. 84 patients (25.3%) received preoperative oncological treatment. We included patients only with R0 resections. 182 patients (56.3%) recovered after the surgery without any complications. Mortality rate was 3.3%. Grade 4 complication developed in 5 (1.5%) patients, while Grade 3 in 26 (8%) patients, Grade 2 in 83 (25.8%) patients, and Grade 1 in 25 (7.7%) patients. During the follow up period 75 (23.3%) patients developed local tumor recurrence and/or distant metastasis. Tumor grade (p = 0.008), stage (p = 0.0001) and histological lympho-vascular invasion of the tumor (p = 0.0001) were associated with increased local and distant tumor recurrence rates. Further, Grade 3 postoperative complications were associated with increased tumor recurrence rate (p = 0.0039) and tumor related mortality (p = 0.05%). application of the modified Clavien Scale is suitable to classify the severity of postoperative complications. Grade 3 complications following elective curative resection of colorectal carcinoma increase local and distant tumor recurrence rates as well as tumor related mortality. Complications developing after colorectal surgery endanger not only the immediate postoperative period, but long term survival is also threatened due to its oncological effect.

Original languageHungarian
Pages (from-to)74-81
Number of pages8
JournalMagyar sebészet
Volume64
Issue number2
DOIs
Publication statusPublished - Apr 2011

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Colorectal Neoplasms
Neoplasm Metastasis
Recurrence
Neoplasms
Colorectal Surgery
Mortality
Postoperative Period
Blood Vessels
Multivariate Analysis
Survival

ASJC Scopus subject areas

  • Medicine(all)

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Hogyan befolyásolják a posztoperatív komplikációk a késoi recidívák és a távoli metastasisok kialakulását colorectalis carcinomák elektív, kuratív resectióját követoen? / Zsoldos, Péter; Hegedüs, László; Issekutz, Akos; Oláh, A.

In: Magyar sebészet, Vol. 64, No. 2, 04.2011, p. 74-81.

Research output: Contribution to journalArticle

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title = "Hogyan befoly{\'a}solj{\'a}k a posztoperat{\'i}v komplik{\'a}ci{\'o}k a k{\'e}soi recid{\'i}v{\'a}k {\'e}s a t{\'a}voli metastasisok kialakul{\'a}s{\'a}t colorectalis carcinom{\'a}k elekt{\'i}v, kurat{\'i}v resecti{\'o}j{\'a}t k{\"o}vetoen?",
abstract = "The aim of the present study is to investigate whether severe postoperative complications following elective colorectal surgery increase local recurrence or distant metastasis rate. 332 patients underwent elective, curative colorectal carcinoma resection in the period between 01.01.2000 and 31.12.2004. Postoperative complications were classified according to the modified Clavien Scale. Complications occurring up to postoperative day 30 were recorded. All complications were analyzed but the most severe one was considered for each patient and included in further analysis. Patients were followed up until 31.12.2009. Univariate and multivariate statistical analyses were performed. The mean age of patients was 64 years, 187 (56{\%}) were male. 84 patients (25.3{\%}) received preoperative oncological treatment. We included patients only with R0 resections. 182 patients (56.3{\%}) recovered after the surgery without any complications. Mortality rate was 3.3{\%}. Grade 4 complication developed in 5 (1.5{\%}) patients, while Grade 3 in 26 (8{\%}) patients, Grade 2 in 83 (25.8{\%}) patients, and Grade 1 in 25 (7.7{\%}) patients. During the follow up period 75 (23.3{\%}) patients developed local tumor recurrence and/or distant metastasis. Tumor grade (p = 0.008), stage (p = 0.0001) and histological lympho-vascular invasion of the tumor (p = 0.0001) were associated with increased local and distant tumor recurrence rates. Further, Grade 3 postoperative complications were associated with increased tumor recurrence rate (p = 0.0039) and tumor related mortality (p = 0.05{\%}). application of the modified Clavien Scale is suitable to classify the severity of postoperative complications. Grade 3 complications following elective curative resection of colorectal carcinoma increase local and distant tumor recurrence rates as well as tumor related mortality. Complications developing after colorectal surgery endanger not only the immediate postoperative period, but long term survival is also threatened due to its oncological effect.",
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