Effect of polysorbates on drug release from wax matrices

J. Dredàn, R. Zelkó, E. Bihari, I. Rácz, E. Gondár

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The purpose of this study was to investigate the effect of various types and amounts of polysorbates on potassium chloride release. Potassium chloride, which is a highly water-soluble model drug, was embedded into wax (containing surfactants) to produce a sustained-release dosage form. Various kinds of polysorbates were chosen as surfactants to control the dissolution profile. The release of the model drug was tested by rotating paddle method of USP 23 and the dissolution process was characterized by the Weibull distribution. The surface tension of the aqueous solutions of polysorbates was determined by a computer-controlled Sigma 70 tensiometer. The application of polysorbates in more than 2% concentration did not alter either the release rate of the embedded potassium chloride, or the surface tension values of the aqueous solutions. The results of this study allow the determination of the optimal concentration of polysorbates in the case of the potassium chloride release.

Original languageEnglish
Pages (from-to)573-576
Number of pages4
JournalDrug development and industrial pharmacy
Volume24
Issue number6
DOIs
Publication statusPublished - Jan 1 1998

    Fingerprint

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

Cite this