Effect of polysorbates on drug release from wax matrices

J. Dredàn, R. Zelkó, E. Bihari, I. Rácz, E. Gondár

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The purpose of this study was to investigate the effect of various types and amounts of polysorbates on potassium chloride release. Potassium chloride, which is a highly water-soluble model drug, was embedded into wax (containing surfactants) to produce a sustained-release dosage form. Various kinds of polysorbates were chosen as surfactants to control the dissolution profile. The release of the model drug was tested by rotating paddle method of USP 23 and the dissolution process was characterized by the Weibull distribution. The surface tension of the aqueous solutions of polysorbates was determined by a computer-controlled Sigma 70 tensiometer. The application of polysorbates in more than 2% concentration did not alter either the release rate of the embedded potassium chloride, or the surface tension values of the aqueous solutions. The results of this study allow the determination of the optimal concentration of polysorbates in the case of the potassium chloride release.

Original languageEnglish
Pages (from-to)573-576
Number of pages4
JournalDrug Development and Industrial Pharmacy
Volume24
Issue number6
Publication statusPublished - 1998

Fingerprint

Polysorbates
Waxes
Potassium Chloride
Surface Tension
Pharmaceutical Preparations
Surface-Active Agents
Surface tension
Dissolution
Weibull distribution
Dosage Forms
Drug Liberation
Water

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology
  • Molecular Medicine

Cite this

Effect of polysorbates on drug release from wax matrices. / Dredàn, J.; Zelkó, R.; Bihari, E.; Rácz, I.; Gondár, E.

In: Drug Development and Industrial Pharmacy, Vol. 24, No. 6, 1998, p. 573-576.

Research output: Contribution to journalArticle

Dredàn, J. ; Zelkó, R. ; Bihari, E. ; Rácz, I. ; Gondár, E. / Effect of polysorbates on drug release from wax matrices. In: Drug Development and Industrial Pharmacy. 1998 ; Vol. 24, No. 6. pp. 573-576.
@article{326f1fc3178c42cb87d10e698cd0c81f,
title = "Effect of polysorbates on drug release from wax matrices",
abstract = "The purpose of this study was to investigate the effect of various types and amounts of polysorbates on potassium chloride release. Potassium chloride, which is a highly water-soluble model drug, was embedded into wax (containing surfactants) to produce a sustained-release dosage form. Various kinds of polysorbates were chosen as surfactants to control the dissolution profile. The release of the model drug was tested by rotating paddle method of USP 23 and the dissolution process was characterized by the Weibull distribution. The surface tension of the aqueous solutions of polysorbates was determined by a computer-controlled Sigma 70 tensiometer. The application of polysorbates in more than 2{\%} concentration did not alter either the release rate of the embedded potassium chloride, or the surface tension values of the aqueous solutions. The results of this study allow the determination of the optimal concentration of polysorbates in the case of the potassium chloride release.",
author = "J. Dred{\`a}n and R. Zelk{\'o} and E. Bihari and I. R{\'a}cz and E. Gond{\'a}r",
year = "1998",
language = "English",
volume = "24",
pages = "573--576",
journal = "Drug Development and Industrial Pharmacy",
issn = "0363-9045",
publisher = "Informa Healthcare",
number = "6",

}

TY - JOUR

T1 - Effect of polysorbates on drug release from wax matrices

AU - Dredàn, J.

AU - Zelkó, R.

AU - Bihari, E.

AU - Rácz, I.

AU - Gondár, E.

PY - 1998

Y1 - 1998

N2 - The purpose of this study was to investigate the effect of various types and amounts of polysorbates on potassium chloride release. Potassium chloride, which is a highly water-soluble model drug, was embedded into wax (containing surfactants) to produce a sustained-release dosage form. Various kinds of polysorbates were chosen as surfactants to control the dissolution profile. The release of the model drug was tested by rotating paddle method of USP 23 and the dissolution process was characterized by the Weibull distribution. The surface tension of the aqueous solutions of polysorbates was determined by a computer-controlled Sigma 70 tensiometer. The application of polysorbates in more than 2% concentration did not alter either the release rate of the embedded potassium chloride, or the surface tension values of the aqueous solutions. The results of this study allow the determination of the optimal concentration of polysorbates in the case of the potassium chloride release.

AB - The purpose of this study was to investigate the effect of various types and amounts of polysorbates on potassium chloride release. Potassium chloride, which is a highly water-soluble model drug, was embedded into wax (containing surfactants) to produce a sustained-release dosage form. Various kinds of polysorbates were chosen as surfactants to control the dissolution profile. The release of the model drug was tested by rotating paddle method of USP 23 and the dissolution process was characterized by the Weibull distribution. The surface tension of the aqueous solutions of polysorbates was determined by a computer-controlled Sigma 70 tensiometer. The application of polysorbates in more than 2% concentration did not alter either the release rate of the embedded potassium chloride, or the surface tension values of the aqueous solutions. The results of this study allow the determination of the optimal concentration of polysorbates in the case of the potassium chloride release.

UR - http://www.scopus.com/inward/record.url?scp=0031775625&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031775625&partnerID=8YFLogxK

M3 - Article

C2 - 9876626

AN - SCOPUS:0031775625

VL - 24

SP - 573

EP - 576

JO - Drug Development and Industrial Pharmacy

JF - Drug Development and Industrial Pharmacy

SN - 0363-9045

IS - 6

ER -