Effect of platelet-rich plasma on the healing of intrabony defects treated with an enamel matrix protein derivative and a natural bone mineral

Ferenc Döri, Dimitris Nikolidakis, Tamás Húszár, Nicole B. Arweiler, I. Gera, Anton Sculean

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: Regenerative periodontal surgery utilizing a combination of an enamel matrix protein derivative (EMD) and a natural bone mineral (NBM) and platelet-rich plasma (PRP) has been shown to enhance the outcomes of regenerative surgery significantly. At present, it is unknown whether root conditioning with EMD, followed by defect fill with a combination of NBM+PRP may additionally enhance the clinical results obtained with EMD+NBM. Aim: To compare clinically the treatment of deep intrabony defects with either EMD+NBM+PRP or EMD+NBM. Material and Methods: Twenty-six patients suffering from advanced chronic periodontitis, and each of whom displayed one advanced intrabony defect were randomly treated with either EMD+NBM+PRP (test) or EMD+NBM (control). The following clinical parameters were evaluated at baseline and at 1 year after treatment: plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), gingival recession (GR) and clinical attachment level (CAL). The primary outcome variable was CAL. Results: Healing was uneventful in all patients. At 1 year after therapy, the test sites showed a reduction in mean PD from 8.8±1.9 mm to 3.1±0.9 mm (p

Original languageEnglish
Pages (from-to)44-50
Number of pages7
JournalJournal of Clinical Periodontology
Volume35
Issue number1
DOIs
Publication statusPublished - Jan 2008

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Platelet-Rich Plasma
Minerals
Bone and Bones
Periodontal Index
Gingival Recession
Chronic Periodontitis
enamel matrix proteins
Therapeutics

Keywords

  • Controlled clinical trial
  • Enamel matrix protein derivative
  • Intrabony defects
  • Natural bone mineral
  • Platelet-rich plasma
  • Regenerative periodontal therapy

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Effect of platelet-rich plasma on the healing of intrabony defects treated with an enamel matrix protein derivative and a natural bone mineral. / Döri, Ferenc; Nikolidakis, Dimitris; Húszár, Tamás; Arweiler, Nicole B.; Gera, I.; Sculean, Anton.

In: Journal of Clinical Periodontology, Vol. 35, No. 1, 01.2008, p. 44-50.

Research output: Contribution to journalArticle

Döri, Ferenc ; Nikolidakis, Dimitris ; Húszár, Tamás ; Arweiler, Nicole B. ; Gera, I. ; Sculean, Anton. / Effect of platelet-rich plasma on the healing of intrabony defects treated with an enamel matrix protein derivative and a natural bone mineral. In: Journal of Clinical Periodontology. 2008 ; Vol. 35, No. 1. pp. 44-50.
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