Effect of platelet-rich plasma on the healing of intrabony defects treated with beta tricalcium phosphate and expanded polytetrafluoroethylene membranes

Ferenc Döri, Tamás Huszár, Dimitris Nikolidakis, Dora Tihanyi, Attila Horváth, Nicole B. Arweiler, I. Gera, Anton Sculean

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Background: Regenerative periodontal therapy using platelet-rich plasma (PRP) and different types of bone substitutes with or without guided tissue regeneration (GTR) has been proposed as a modality to enhance the outcome of regenerative surgery. However, there are limited data from controlled clinical studies evaluating the effect of PRP on the healing of deep intrabony defects treated with a combination of bone substitutes and GTR. The aim of this study was to clinically evaluate the effect of PRP on the healing of deep intrabony defects treated with beta tricalcium phosphate (β-TCP) and GTR by means of a non-bioresorbable expanded polytetrafluoroethylene membrane. Methods: Twenty-eight subjects with advanced chronic periodontal disease and displaying one intrabony defect were treated randomly with a combination of PRP + β-TCP + GTR or β-TCP + GTR. Plaque index, gingival index, bleeding on probing, probing depth (PD), gingival recession, and clinical attachment level (CAL) were evaluated at baseline and at 1 year after treatment. CAL was the primary outcome variable. Results: No differences in any of the investigated parameters were observed at baseline between the two groups. Healing was uneventful in all subjects. At 1 year after therapy, the sites treated with PRP + β-TCP + GTR showed a reduction in mean PD from 9.1 ± 0.6 mm to 3.3 ± 0.5 mm (P

Original languageEnglish
Pages (from-to)660-669
Number of pages10
JournalJournal of Periodontology
Volume79
Issue number4
DOIs
Publication statusPublished - Apr 2008

Fingerprint

Guided Tissue Regeneration
Platelet-Rich Plasma
Polytetrafluoroethylene
Membranes
Bone Substitutes
Periodontal Index
Gingival Recession
Periodontal Diseases
beta-tricalcium phosphate
Chronic Disease
Therapeutics

Keywords

  • Beta tricalcium phosphate
  • Defects
  • Platelet-rich plasma
  • Polytetrafluoroethylene
  • Randomized controlled clinical trials
  • Therapy

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Effect of platelet-rich plasma on the healing of intrabony defects treated with beta tricalcium phosphate and expanded polytetrafluoroethylene membranes. / Döri, Ferenc; Huszár, Tamás; Nikolidakis, Dimitris; Tihanyi, Dora; Horváth, Attila; Arweiler, Nicole B.; Gera, I.; Sculean, Anton.

In: Journal of Periodontology, Vol. 79, No. 4, 04.2008, p. 660-669.

Research output: Contribution to journalArticle

Döri, Ferenc ; Huszár, Tamás ; Nikolidakis, Dimitris ; Tihanyi, Dora ; Horváth, Attila ; Arweiler, Nicole B. ; Gera, I. ; Sculean, Anton. / Effect of platelet-rich plasma on the healing of intrabony defects treated with beta tricalcium phosphate and expanded polytetrafluoroethylene membranes. In: Journal of Periodontology. 2008 ; Vol. 79, No. 4. pp. 660-669.
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