Effect of plasticizer on surface of free films prepared from aqueous solutions of salts of cationic polymers with different plasticizers

János Bajdik, Máté Fehér, K. Pintye-Hódi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Acquisition of a more detailed understanding of all technological processes is currently a relevant tendency in pharmaceutical technology and hence in industry. A knowledge of film formation from dispersion of polymers is very important during the coating of solid dosage forms. This process and the structure of the film can be influenced by different additives. In the present study, taste-masking films were prepared from aqueous citric acid solutions of a cationic polymer (Eudragit® E PO) with various hydrophilic plasticizers (glycerol, propylene glycol and different poly(ethylene glycols)). The mechanical properties, film thickness, wetting properties and surface free energy of the free films were studied. The aim was to evaluate the properties of surface of free films to predict the arrangement of macromolecules in films formed from aqueous solutions of salts of cationic polymers. A high molecular weight of the plasticizer decreased the work of deformation. The surface free energy and the polarity were highest for the film without plasticizer; the hydrophilic additives decreased these parameters. The direction of the change in polarity (a hydrophilic component caused a decrease in the polarity) was unexpected. It can be explained by the change in orientation of the macromolecules, a hydrophobic surface being formed. Examination of the mechanical properties and film thickness can furnish additional results towards a knowledge of film formation by this not frequently applied type of polymer from aqueous solution.

Original languageEnglish
Pages (from-to)7303-7308
Number of pages6
JournalApplied Surface Science
Volume253
Issue number17
DOIs
Publication statusPublished - Jun 30 2007

Fingerprint

Plasticizers
plasticizers
Polymers
Salts
aqueous solutions
salts
polymers
polarity
Macromolecules
macromolecules
Free energy
Film thickness
glycols
film thickness
free energy
mechanical properties
taste
Mechanical properties
Propylene Glycol
citric acid

Keywords

  • Mechanical properties
  • Plasticizer
  • Polarity
  • Salts of cationic polymers
  • Surface free energy

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Condensed Matter Physics

Cite this

Effect of plasticizer on surface of free films prepared from aqueous solutions of salts of cationic polymers with different plasticizers. / Bajdik, János; Fehér, Máté; Pintye-Hódi, K.

In: Applied Surface Science, Vol. 253, No. 17, 30.06.2007, p. 7303-7308.

Research output: Contribution to journalArticle

@article{c6982d9ed2b144b5bb885956e4eaceac,
title = "Effect of plasticizer on surface of free films prepared from aqueous solutions of salts of cationic polymers with different plasticizers",
abstract = "Acquisition of a more detailed understanding of all technological processes is currently a relevant tendency in pharmaceutical technology and hence in industry. A knowledge of film formation from dispersion of polymers is very important during the coating of solid dosage forms. This process and the structure of the film can be influenced by different additives. In the present study, taste-masking films were prepared from aqueous citric acid solutions of a cationic polymer (Eudragit{\circledR} E PO) with various hydrophilic plasticizers (glycerol, propylene glycol and different poly(ethylene glycols)). The mechanical properties, film thickness, wetting properties and surface free energy of the free films were studied. The aim was to evaluate the properties of surface of free films to predict the arrangement of macromolecules in films formed from aqueous solutions of salts of cationic polymers. A high molecular weight of the plasticizer decreased the work of deformation. The surface free energy and the polarity were highest for the film without plasticizer; the hydrophilic additives decreased these parameters. The direction of the change in polarity (a hydrophilic component caused a decrease in the polarity) was unexpected. It can be explained by the change in orientation of the macromolecules, a hydrophobic surface being formed. Examination of the mechanical properties and film thickness can furnish additional results towards a knowledge of film formation by this not frequently applied type of polymer from aqueous solution.",
keywords = "Mechanical properties, Plasticizer, Polarity, Salts of cationic polymers, Surface free energy",
author = "J{\'a}nos Bajdik and M{\'a}t{\'e} Feh{\'e}r and K. Pintye-H{\'o}di",
year = "2007",
month = "6",
day = "30",
doi = "10.1016/j.apsusc.2007.03.013",
language = "English",
volume = "253",
pages = "7303--7308",
journal = "Applied Surface Science",
issn = "0169-4332",
publisher = "Elsevier",
number = "17",

}

TY - JOUR

T1 - Effect of plasticizer on surface of free films prepared from aqueous solutions of salts of cationic polymers with different plasticizers

AU - Bajdik, János

AU - Fehér, Máté

AU - Pintye-Hódi, K.

PY - 2007/6/30

Y1 - 2007/6/30

N2 - Acquisition of a more detailed understanding of all technological processes is currently a relevant tendency in pharmaceutical technology and hence in industry. A knowledge of film formation from dispersion of polymers is very important during the coating of solid dosage forms. This process and the structure of the film can be influenced by different additives. In the present study, taste-masking films were prepared from aqueous citric acid solutions of a cationic polymer (Eudragit® E PO) with various hydrophilic plasticizers (glycerol, propylene glycol and different poly(ethylene glycols)). The mechanical properties, film thickness, wetting properties and surface free energy of the free films were studied. The aim was to evaluate the properties of surface of free films to predict the arrangement of macromolecules in films formed from aqueous solutions of salts of cationic polymers. A high molecular weight of the plasticizer decreased the work of deformation. The surface free energy and the polarity were highest for the film without plasticizer; the hydrophilic additives decreased these parameters. The direction of the change in polarity (a hydrophilic component caused a decrease in the polarity) was unexpected. It can be explained by the change in orientation of the macromolecules, a hydrophobic surface being formed. Examination of the mechanical properties and film thickness can furnish additional results towards a knowledge of film formation by this not frequently applied type of polymer from aqueous solution.

AB - Acquisition of a more detailed understanding of all technological processes is currently a relevant tendency in pharmaceutical technology and hence in industry. A knowledge of film formation from dispersion of polymers is very important during the coating of solid dosage forms. This process and the structure of the film can be influenced by different additives. In the present study, taste-masking films were prepared from aqueous citric acid solutions of a cationic polymer (Eudragit® E PO) with various hydrophilic plasticizers (glycerol, propylene glycol and different poly(ethylene glycols)). The mechanical properties, film thickness, wetting properties and surface free energy of the free films were studied. The aim was to evaluate the properties of surface of free films to predict the arrangement of macromolecules in films formed from aqueous solutions of salts of cationic polymers. A high molecular weight of the plasticizer decreased the work of deformation. The surface free energy and the polarity were highest for the film without plasticizer; the hydrophilic additives decreased these parameters. The direction of the change in polarity (a hydrophilic component caused a decrease in the polarity) was unexpected. It can be explained by the change in orientation of the macromolecules, a hydrophobic surface being formed. Examination of the mechanical properties and film thickness can furnish additional results towards a knowledge of film formation by this not frequently applied type of polymer from aqueous solution.

KW - Mechanical properties

KW - Plasticizer

KW - Polarity

KW - Salts of cationic polymers

KW - Surface free energy

UR - http://www.scopus.com/inward/record.url?scp=34249096885&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249096885&partnerID=8YFLogxK

U2 - 10.1016/j.apsusc.2007.03.013

DO - 10.1016/j.apsusc.2007.03.013

M3 - Article

VL - 253

SP - 7303

EP - 7308

JO - Applied Surface Science

JF - Applied Surface Science

SN - 0169-4332

IS - 17

ER -