The retention of sixteen monoamine oxidase inhibitory drugs (proparlgylamine derivatives) was determined on a porous graphitized carbon (PGC) column using ethanol-water mixtures as eluents. The HPLC retention characteristics of drugs were correlated with their physicochemical properties using stepwise regression analysis and principal component (PC) analysis. The dimensions of the matrices for PC loadings and variables was reduced using a non-linear mapping technique, varimax rotation and cluster analysis. It has been established that the drugs can be well separated on the PGC column in ethanol-water eluents. Calculations proved that the retention behavior of monoamine oxidase drugs on PGC column is of mixed character: both steric and electronic parameters influence the retention.
|Number of pages||8|
|Journal||Journal of Chromatography B: Biomedical Applications|
|Publication status||Published - May 31 1996|
- Monoamine oxidase
- Porous graphitized carbon columns
ASJC Scopus subject areas