Effect of phenylethanolamine N-methyltransferase inhibition on serum concentrations of luteinizing hormone, follicle stimulating hormone and prolactin in pro-oestrous and ovariectomized rats

Clive W. Coen, Agnes Simonyi, Marton I.K. Fekete

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In a dose dependent manner, LY 87130, an inhibitor of adrenaline synthesis in the rat brain, either shifts the pro-oestrous surges of luteinizing hormone and follicle stimulating hormone from the late afternoon to the middle of the night or blocks any occurence of the surges and prevents ovulation. Because the pulsatile release of LH is also blocked by LY 87130, it is proposed that the role of adrebaline in the production of the preovulatory surge is concerned with the regulation of the LH pulses which constitute the surge.

Original languageEnglish
Pages (from-to)383-387
Number of pages5
JournalBrain research
Volume343
Issue number2
DOIs
Publication statusPublished - Sep 23 1985

Keywords

  • adrenaline
  • follicle stimulating hormone
  • luteinizing hormone
  • ovulation
  • phenylethanolamine N-methyltransferase
  • prolactin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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