Effect of phenoxybenzamine and propranolol on myocardial reactive hyperaemia in fibrillating canine heart

C. Farsang, Lóránd Debreczeni, Ágnes Kerényi, Lajos Takács

Research output: Contribution to journalArticle

Abstract

In order to evaluate whether alpha and beta adrenergic mechanisms participate in the coronary reactive hyperaemia, effects of phenoxybenzamine (10 mg per kg b.w.) or propranolol (2 mg per kg b.w.), or phenoxybenzamine + propranolol on reactive hyperaemic responses following 15, 30, 60 and 120 s occlusions of left coronary vessels were investigated on isolated fibrillating, blood-perfused dog heart preparations. Hearts were either perfused at constant pressure or at constant volume on the basal perfusion pressure of 150 mm Hg. Phenoxybenzamine induced marked vasodilatation while the postocclusion reaction slightly increased when hearts were perfused at constant pressure. Upon application of propranolol both basal conductance and postocclusion reaction was considerably decreased. After phenoxybenzamine pretreatment propranolol did not change the maximum postocclusion coronary dilatation, but the duration of reactive hyperaemia however, was decreased. It can be concluded that alpha and beta adrenergic receptors are involved in the regulation of coronary circulation of fibrillating canine heart either in the control state or during postocclusion period. Alpha receptors seem to determine the degree of coronary dilatation after the release of occlusion, while beta receptors may control primarily the duration of reactive hyperaemia.

Original languageEnglish
Pages (from-to)223-228
Number of pages6
JournalPflugers Archiv European Journal of Physiology
Volume379
Issue number3
DOIs
Publication statusPublished - Apr 1979

Fingerprint

Phenoxybenzamine
Hyperemia
Propranolol
Canidae
Pressure
Dilatation
Receptors, Adrenergic, alpha
Coronary Circulation
Receptors, Adrenergic, beta
Vasodilation
Adrenergic Agents
Coronary Vessels
Blood
Perfusion
Dogs

Keywords

  • Adrenergic receptor blockade
  • Coronary adaptation to ischaemia
  • Coronary conductance
  • Postocclusion hyperaemia

ASJC Scopus subject areas

  • Physiology

Cite this

Effect of phenoxybenzamine and propranolol on myocardial reactive hyperaemia in fibrillating canine heart. / Farsang, C.; Debreczeni, Lóránd; Kerényi, Ágnes; Takács, Lajos.

In: Pflugers Archiv European Journal of Physiology, Vol. 379, No. 3, 04.1979, p. 223-228.

Research output: Contribution to journalArticle

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