Effect of phenothiazines, benzo[a]phenothiazines, benz[c]acridines and pentaglobin on endotoxin

J. Molnár, Y. Mándi, J. Foldes, S. Foldeak, A. Molnár, N. Motohashi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The endotoxin neutralizing effects of several phenothiazines, benzophenothiazines and Pentaglobin (control) were investigated by spectrophotometry, tumor necrosis factor (TNF) induction and the conventional Limulus test. In animal experiments, some beneficial effects of complex forming compounds were found, however, the compounds could not completely inactivate the biological effect of endotoxin in the Limulus test. The complex formation between endotoxin and the compounds were revealed in spectrophotometry. The TNF inducing effect of compound-endotoxin complexes was markedly reduced by some phenothiazines and benzo[a]phenothiazines in leukocytes. Benz[c]acridines and Pentaglobin could not neutralize completely the TNF induction of E. coli endotoxin. The recent findings indicate that multifocal effects of phenothiazines and benzophenothiazines can be responsible for anti-endotoxin action in vivo. Hypotensive action in experimental animals was reduced by some phenothiazines in some preliminary experiments.

Original languageEnglish
Pages (from-to)463-468
Number of pages6
JournalIn Vivo
Volume9
Issue number5
Publication statusPublished - 1995

Fingerprint

Phenothiazines
Endotoxins
Limulus Test
Tumor Necrosis Factor-alpha
Spectrophotometry
Animals
Escherichia coli
pentaglobulin
benzophenothiazine
benz(c)acridine
Leukocytes
Experiments

Keywords

  • Benzo[a]phenothiazines benz[c]acridines
  • Complex
  • Endotoxin
  • Pentaglobin
  • Phenothiazines

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effect of phenothiazines, benzo[a]phenothiazines, benz[c]acridines and pentaglobin on endotoxin. / Molnár, J.; Mándi, Y.; Foldes, J.; Foldeak, S.; Molnár, A.; Motohashi, N.

In: In Vivo, Vol. 9, No. 5, 1995, p. 463-468.

Research output: Contribution to journalArticle

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AU - Molnár, A.

AU - Motohashi, N.

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