Effect of pesticides on kynurenic acid production in rat brain slices

Elzbieta Zielińska, Tomasz Kocki, Tomasz Saran, Sandor Borbely, Damian Kuc, I. Világi, Ewa M. Urbańska, Waldemar A. Turski

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Kynurenic acid (KYNA) is a broad spectrum antagonist of ionotropic glutamate receptors, preferentially active at the strychnine-insensitive glycine allosteric site of the N-methyl-D-aspartate (NMDA) receptor, and a noncompetitive antagonist of alpha7 nicotinic receptor. Animal studies showed that it possesses anticonvulsant and neuroprotective properties. Its involvement in the pathophysiology of various brain disorders was suggested. In this study, the effect of pesticides on KYNA production in brain cortical slices was investigated. Pyrethroids, deltamethrin and fenpropathrin significantly lowered KYNA production. Methomyl, bensultap, fipronil, diquat and MCPA were ineffective in this regard. In view of this data, the inhibition of KYNA synthesis appear to merit further investigation as a potential factor contributing to the toxicology of pyrethroids.

Original languageEnglish
Pages (from-to)177-179
Number of pages3
JournalAnnals of Agriculture and Environmental Medicine
Volume12
Issue number2
Publication statusPublished - 2005

Fingerprint

Kynurenic Acid
Pesticides
brain
Rats
Brain
pesticides
pesticide
Pyrethrins
fenpropathrin
pyrethroid
acids
acid
rats
pyrethrins
antagonists
2-Methyl-4-chlorophenoxyacetic Acid
Methomyl
Diquat
diquat
strychnine

Keywords

  • Kynurenic acid
  • Pesticide
  • Rat brain slices

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Zielińska, E., Kocki, T., Saran, T., Borbely, S., Kuc, D., Világi, I., ... Turski, W. A. (2005). Effect of pesticides on kynurenic acid production in rat brain slices. Annals of Agriculture and Environmental Medicine, 12(2), 177-179.

Effect of pesticides on kynurenic acid production in rat brain slices. / Zielińska, Elzbieta; Kocki, Tomasz; Saran, Tomasz; Borbely, Sandor; Kuc, Damian; Világi, I.; Urbańska, Ewa M.; Turski, Waldemar A.

In: Annals of Agriculture and Environmental Medicine, Vol. 12, No. 2, 2005, p. 177-179.

Research output: Contribution to journalArticle

Zielińska, E, Kocki, T, Saran, T, Borbely, S, Kuc, D, Világi, I, Urbańska, EM & Turski, WA 2005, 'Effect of pesticides on kynurenic acid production in rat brain slices', Annals of Agriculture and Environmental Medicine, vol. 12, no. 2, pp. 177-179.
Zielińska, Elzbieta ; Kocki, Tomasz ; Saran, Tomasz ; Borbely, Sandor ; Kuc, Damian ; Világi, I. ; Urbańska, Ewa M. ; Turski, Waldemar A. / Effect of pesticides on kynurenic acid production in rat brain slices. In: Annals of Agriculture and Environmental Medicine. 2005 ; Vol. 12, No. 2. pp. 177-179.
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