Effect of pesticides on kynurenic acid production in rat brain slices

Elzbieta Zielińska, Tomasz Kocki, Tomasz Saran, Sandor Borbely, Damian Kuc, Ildiko Vilagi, Ewa M. Urbańska, Waldemar A. Turski

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Abstract

Kynurenic acid (KYNA) is a broad spectrum antagonist of ionotropic glutamate receptors, preferentially active at the strychnine-insensitive glycine allosteric site of the N-methyl-D-aspartate (NMDA) receptor, and a noncompetitive antagonist of alpha7 nicotinic receptor. Animal studies showed that it possesses anticonvulsant and neuroprotective properties. Its involvement in the pathophysiology of various brain disorders was suggested. In this study, the effect of pesticides on KYNA production in brain cortical slices was investigated. Pyrethroids, deltamethrin and fenpropathrin significantly lowered KYNA production. Methomyl, bensultap, fipronil, diquat and MCPA were ineffective in this regard. In view of this data, the inhibition of KYNA synthesis appear to merit further investigation as a potential factor contributing to the toxicology of pyrethroids.

Original languageEnglish
Pages (from-to)177-179
Number of pages3
JournalAnnals of Agricultural and Environmental Medicine
Volume12
Issue number2
Publication statusPublished - Dec 1 2005

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Keywords

  • Kynurenic acid
  • Pesticide
  • Rat brain slices

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Waste Management and Disposal
  • Public Health, Environmental and Occupational Health

Cite this

Zielińska, E., Kocki, T., Saran, T., Borbely, S., Kuc, D., Vilagi, I., Urbańska, E. M., & Turski, W. A. (2005). Effect of pesticides on kynurenic acid production in rat brain slices. Annals of Agricultural and Environmental Medicine, 12(2), 177-179.