Effect of perinatal vitamin A or retinoic acid treatment (hormonal imprinting) on the sexual behavior of adult rats

György Csaba, Annamária Gaál

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Single neonatal treatment with vitamin A (retinol) dramatically reduced the sexual activity of adult male rats. In females there was a significant decrease in the Meyerson index and a non significant decrease in the lordosis quotient. The effect of three perinatal treatments (at the first, third and fifth day) with all-trans retinoic acid was much weaker, causing only a significant increase in the time of the first ejaculation in males and non- significant decrease in the lordosis quotient of females. The experiments call attention to the false imprinting provoking effect of materials acting on members of the steroid receptor superfamily with possible human health aspect.

Original languageEnglish
Pages (from-to)193-197
Number of pages5
JournalHuman & Experimental Toxicology
Volume16
Issue number4
DOIs
Publication statusPublished - Apr 1997

Keywords

  • hormonal imprint ing
  • neonatal treatment
  • retinoic acid
  • retinol
  • steroids
  • vitamin A

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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