Effect of perinatal synthetic steroid hormone (allylestrenol, diethylstilbestrol) treatment (hormonal imprinting) on the bone mineralization of the adult male and female rat

Cs Karabélyos, Cs Horváth, I. Holló, G. Csaba

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Neonatal treatment with allylestrenol or diethylstilbestrol (DES) reduced the bone mineral content (BMC/bw) of the adult (four months old) female rats, without influencing bone mineral density (BMD/bw). In males these neonatal treatments elevated BMC and BMD alike. Ovariectomy alone decreased BMC and BMD alike; however the neonatal hormone treatments did not influence this reduced value. Ovariectomy of two months old animals increased body weight without the influence of neonatal hormone treatments. In adult males, the body weight was reduced significantly by neonatal DES and non- significantly by neonatal allylestrenol treatment. The experiments call attention to the possible human bone-effects of allylestrenol, which was used in the last decades as medication protecting endangered pregnancies.

Original languageEnglish
Pages (from-to)PL105-PL110
JournalLife sciences
Volume64
Issue number9
DOIs
Publication statusPublished - Jan 22 1999

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Keywords

  • Allylestrenol
  • Body weight
  • Bone mineralization
  • Diethylstilbestrol
  • Hormonal imprinting
  • Synthetic estrogens

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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