Effect of perinatal stress on the biogenic amine neurotransmitter level of the adult rat's brain

Kornélia Tekes, P. Szegi, R. Laufer, M. Hantos, G. Csaba

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9 Citations (Scopus)

Abstract

The amount of biogenic amines (dopamine and serotonin) and their metabolites (DOPAC, HVA, 5-HIAA, and 5-HTOL) in five regions of the brain (frontal cortex, hypothalamus, hippocampus, striatum, and brainstem) was studied in the male and female offspring of control and perinatally (48. h before birth or 48. h after birth) food and water deprived dams, when they were three months old, by using HPLC-EC determination. The increase of amine or metabolite level was dominant (19 values increased and 10 decreased related to control). Before-birth stress caused increase in 9 case and only 2 decreased, while in the case of after-birth stress 10 increased and 8 decreased. However, though there is no possibility to decide an exact tendency of direction, the after-birth stress (transmitted by milk) has more expressed effect. Striatum and brainstem were the most touched regions. There was a gender dependence with the dominance of males, except striatum. Blood plasma nociceptin level was also studied and there was a significant elevation in males after pre- and postnatal deprivation, while in females only after postnatal deprivation. The importance of the results in correlation with other stress effects is discussed.

Original languageEnglish
Pages (from-to)171-175
Number of pages5
JournalInternational Journal of Developmental Neuroscience
Volume29
Issue number2
DOIs
Publication statusPublished - Apr 1 2011

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Keywords

  • Biogenic amines
  • Brain
  • Hormonal imprinting
  • Nociceptin
  • Stress

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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