A pentoxifyllinum hatása a kísérletes bal colonfél anasztomózis gyógyulására.

Translated title of the contribution: Effect of pentoxifylline on the healing of experimental anastomosis of the left colon in rats

F. Ender, T. Labancz, I. Furka, E. M. Gamal, J. Fúrész, L. Rosivall

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The healing of colonic anastomoses is determined by several factors such as microcirculation, the strength of the inflammatory response, and the time required for regeneration. We investigated the effects of pentoxifylline--a drug which improves microcirculation and modulates leukocyte functions--on the healing of experimental anastomosis on the left colon of rats. As a result of drug treatment (0.25 mg/100 g, i.p.) in Group I anastomosis bursting pressure (ABP) was by 56 +/- 17% higher at day 2 than in controls with no pentoxifylline treatment. On the 5th postoperative day in Group I, ABP reached 80 +/- 8% the value for the intact colon (218 +/- 21 mmHg), whereas respective value in the control (untreated) group was only 47 +/- 7%. In Group II (pentoxifylline: 2 mg/100 g, i.p.) ABP was by 55 +/- 10% and by 73 +/- 8% higher than control values at postoperative days 1 and 2, respectively. At day 2, in Group I colonic blood flow measured at the anastomosis line by 86Rb uptake technique was significantly higher than in the untreated controls (0.18 +/- 0.01 ml/min vs. 0.14 +/- 0.01 ml/min, (p <0.02). Blood flow measured in colon tissue above and below the anastomosis changed differently. Pentoxifylline treatment also suppressed the peritoneal inflammatory response assessed with peritoneal reaction index (2.0 +/- 0.3 vs. 1.1 +/- 0.2, p <0.01). The results of the present study show that pentoxifylline treatment shortens the time needed for the healing of colonic anastomosis. These observations suggest that pentoxifylline medication can prevent failure of colonic anastomoses.

Original languageHungarian
Pages (from-to)185-190
Number of pages6
JournalMagyar sebészet
Volume54
Issue number3
Publication statusPublished - 2001

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Pentoxifylline
Colon
Microcirculation
Pressure
Pharmaceutical Preparations
Reaction Time
Regeneration
Leukocytes
Therapeutics
Control Groups

Cite this

A pentoxifyllinum hatása a kísérletes bal colonfél anasztomózis gyógyulására. / Ender, F.; Labancz, T.; Furka, I.; Gamal, E. M.; Fúrész, J.; Rosivall, L.

In: Magyar sebészet, Vol. 54, No. 3, 2001, p. 185-190.

Research output: Contribution to journalArticle

Ender, F, Labancz, T, Furka, I, Gamal, EM, Fúrész, J & Rosivall, L 2001, 'A pentoxifyllinum hatása a kísérletes bal colonfél anasztomózis gyógyulására.', Magyar sebészet, vol. 54, no. 3, pp. 185-190.
Ender, F. ; Labancz, T. ; Furka, I. ; Gamal, E. M. ; Fúrész, J. ; Rosivall, L. / A pentoxifyllinum hatása a kísérletes bal colonfél anasztomózis gyógyulására. In: Magyar sebészet. 2001 ; Vol. 54, No. 3. pp. 185-190.
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