Effect of particle size and coating level on the diffuse reflectance of wax matrices

J. Dredán, R. Zelkó, I. Antal, E. Bihari, I. Rácz

Research output: Contribution to journalArticle

10 Citations (Scopus)


The aim of this study was to examine the influence of particle size and extent of coating on the diffuse-reflectance spectra of wax matrices containing embedded potassium chloride. Near-infrared spectroscopy was used to analyse the diffuse-reflectance characteristics of the prepared multi-particulate matrices without destructive sample preparation. A 2-factor, 3-level face-centred central composite design was selected to construct a second-order polynomial model which described the effect of particle size and amount of coating on the intensity of the diffusely reflected light. A non-linear model was used to demonstrate the effect of the selected parameters on the intensity of the reflected light; good correlation was obtained between experimental and predicted results. The results indicated that the extent of coating and the particle size of the examined systems in the selected particle size-range modified the intensity of the reflected light. It can be concluded that near-infrared spectroscopy is a sensitive means of measuring not only the particle size of powders (substrates and their mixtures), but also that of coated multi-particulate systems.

Original languageEnglish
Pages (from-to)139-142
Number of pages4
JournalJournal of Pharmacy and Pharmacology
Issue number2
Publication statusPublished - Feb 1998

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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