Effect of parenteral or oral vinpocetine on the hemorheological parameters of patients with chronic cerebrovascular diseases

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11 Citations (Scopus)

Abstract

Introduction: Hemorheological factors play an important role in the pathomechanism of ischemic cerebrovascular disorders. Abnormal rheological conditions in patients with chronic cerebrovascular disease predispose for recurrent strokes. Vinpocetine (VP), a synthetic ethyl esther of apovincamine, has successfully been used in the treatment of cerebrovascular diseases, in part because of its favourable rheological effects. Patients and methods: The study investigates the hemorheological changes in 40 patients in the chronic stage of ischemic cardiovascular disease after administration of vinpocetine. All patients received a high dose of intravenous VP in doses gradually increased to l mg/kg/day. In addition, 20 patients (mean age: 61±8 years) received 30 mg VP orally for 3 months. The other 20 patients (mean age: 59±6 years), who received placebo tablets, served as controls. Hemorheological parameters (hematocrit, plasma fibrinogen, whole blood viscosity, red blood cell aggregation and deformability) were evaluated at 1 and 3 months. Results: The high-dose parenteral VP significantly decreased red blood cell aggregation, plasma and whole blood viscosity (p<0.05) compared to the initial values. In patients with additional oral treatment, plasma and whole blood viscosities were significantly lower compared to the placebo patients at 3 months (p<0.05). Conclusion: Our results confirmed the beneficial rheological effects of high-dose parenteral VP (partially caused by hemodilution) observed previously, and also warrant its long-term oral admission to maintain the beneficial rheological changes.

Original languageEnglish
Pages (from-to)111-117
Number of pages7
JournalPhytomedicine
Volume16
Issue number2-3
DOIs
Publication statusPublished - Mar 1 2009

Keywords

  • Chronic cerebrovascular diseases
  • Ethylapovincaminate
  • Hemorheological parameters
  • Parenteral and oral administration
  • Vinpocetine

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

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