Paracetamol hatása a vörösvérsejtek savi haemolysisére, különös tekintettel az intracellularis glutathion szintre.

Translated title of the contribution: Effect of paracetamol on the acid hemolysis of erythrocytes, with special reference to the intracellular glutathione level

I. Altorjay, B. Sári, S. Imre, G. Balla, L. Dalmi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The authors give account of their study concerning the effect of paracetamol on the acid haemolysis, and glutathione content of human erythrocytes. In vitro, paracetamol decreased intracellular glutathione content in a dose dependent manner. This may lead to an increased sensitivity of erythrocytes to the haemolytic effect of hydrochloric acid, what may explain the dose dependent decrease of time of haemolysis, presented in form of dynamic haemolysis curve. In vivo four hours following the oral intake of 500 mg paracetamol, although the intracellular glutathione content did not decrease significantly, shortening of the time of acid haemolysis could be demonstrated in more than half of the persons studied. No haemolysis was caused by the given dose of the drug.

Translated title of the contributionEffect of paracetamol on the acid hemolysis of erythrocytes, with special reference to the intracellular glutathione level
Original languageHungarian
Pages (from-to)2259-2262
Number of pages4
JournalOrvosi hetilap
Volume134
Issue number41
Publication statusPublished - Oct 10 1993

ASJC Scopus subject areas

  • Medicine(all)

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