Effect of pancreatic polypeptide on the motility of the guinea-pig small intestine in vitro

P. Holzer, L. Barthó, I. T. Lippe, W. Petritsch, G. Leb

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The effect of porcine pancreatic polypeptide (PP) on the motor activity of the longitudinal and circular muscles of the guinea-pig isolated small intestine was investigated. PP (0.2-20 nM) inhibited cholinergic contractions of the longitudinal muscle in response to electrical field stimulation, the maximal effect being a 30% reduction of the contraction amplitude. Carbachol-induced contractions of the longitudinal muscle were not affected by PP (10 nM). PP (0.3-30 nM) also inhibited reflex contractions of the circular muscle elicited by balloon distension and recorded orally to the site of distension; the maximal effect was a 80% reduction of the reflex contraction. In contrast, carbachol-induced contractions of the circular muscle remained unaltered by PP (10 nM). It was further found that PP (10 and 100 nM) enhanced the threshold intraluminal pressure at which peristaltic waves were triggered. All these effects of PP appeared to be transient. Taken together, these data indicate that PP does not act on intestinal smooth muscle but can modulate the activity of certain enteric neurones which are involved in the regulation of intestinal motility.

Original languageEnglish
Pages (from-to)305-314
Number of pages10
JournalRegulatory Peptides
Volume16
Issue number3-4
DOIs
Publication statusPublished - Dec 30 1986

Keywords

  • enteric nervous system
  • enteric reflexes
  • guinea-pig small intestine
  • intestinal peristalsis
  • intestinal smooth muscle
  • pancreatic polypeptide

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

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