A pancreas-transzplantáció hatása a triglycerid-anyagcserére.

Translated title of the contribution: Effect of pancreas transplantation on triglyceride metabolism

G. Pálos, J. Domán, B. Föger, I. Karádi, L. Romics

Research output: Contribution to journalArticle

Abstract

Transplantation of pancreatic gland with systemic venous drainage of the graft causes elevated plasma levels of insulin. To examine lipid metabolism triglyceride clearance capacity, lipolytic enzymes, plasma lipids and lipoproteins were quantified in pancreas-kidney transplant recipients and compared them to lipid parameters of healthy controls and those of patients who had received only kidney transplants. Eleven pancreas-kidney transplant recipients with type I diabetes, 9 non-diabetic kidney transplant recipients as controls for the effects of immunosuppressive medication, and 11 healthy controls were studied. In pancreas-kidney transplant recipients fasting cholesterol, non-HDL cholesterol, triglyceride levels were found 5.5 (+/- 1.0), 3.4 (+/- 0.78) and 1.06 (+/- 0.29) respectively and expressed in mmol/L (mean +/- SE). The results were statistically not different from those of healthy controls. In contrast, non-diabetic kidney transplant recipients cholesterol, non-HDL cholesterol and triglyceride levels were increased to 6.1 (+/- 0.81) (p <0.05), 4.6 (+/- 1.1) (p <0.05) and 2.34 (+/- 1.53) mmol/L (p <0.05). HDL cholesterol averaged 2.08 (+/- 0.36) in pancreas-kidney transplant recipients, clearly higher than that of kidney transplant recipients 1.53 (+/- 0.39) mmol/L (p > 0.01), or of controls 1.61 (+/- 0.37) mmol/L (p <0.05). In pancreas-kidney transplant recipients postprandial lipaemia was the lowest and lipase activity was the highest compared both to kidney transplant recipients (p <0.001, p <0.05) and controls (p <0.01, p <0.05). This excellent triglyceride clearing capacity appears to be the result of a high activity of lipoprotein lipase, which, can be explained by the peripheral hyperinsulinaemia.

Original languageHungarian
Pages (from-to)2609-2614
Number of pages6
JournalOrvosi Hetilap
Volume136
Issue number48
Publication statusPublished - Nov 26 1995

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Pancreas Transplantation
Triglycerides
Kidney
Pancreas
HDL Cholesterol
Cholesterol
Transplants
Lipids
Lipoprotein Lipase
Hyperinsulinism
Immunosuppressive Agents
Transplant Recipients
Lipase
Type 1 Diabetes Mellitus
Lipid Metabolism
Lipoproteins
Drainage
Fasting
Transplantation
Insulin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pálos, G., Domán, J., Föger, B., Karádi, I., & Romics, L. (1995). A pancreas-transzplantáció hatása a triglycerid-anyagcserére. Orvosi Hetilap, 136(48), 2609-2614.

A pancreas-transzplantáció hatása a triglycerid-anyagcserére. / Pálos, G.; Domán, J.; Föger, B.; Karádi, I.; Romics, L.

In: Orvosi Hetilap, Vol. 136, No. 48, 26.11.1995, p. 2609-2614.

Research output: Contribution to journalArticle

Pálos, G, Domán, J, Föger, B, Karádi, I & Romics, L 1995, 'A pancreas-transzplantáció hatása a triglycerid-anyagcserére.', Orvosi Hetilap, vol. 136, no. 48, pp. 2609-2614.
Pálos G, Domán J, Föger B, Karádi I, Romics L. A pancreas-transzplantáció hatása a triglycerid-anyagcserére. Orvosi Hetilap. 1995 Nov 26;136(48):2609-2614.
Pálos, G. ; Domán, J. ; Föger, B. ; Karádi, I. ; Romics, L. / A pancreas-transzplantáció hatása a triglycerid-anyagcserére. In: Orvosi Hetilap. 1995 ; Vol. 136, No. 48. pp. 2609-2614.
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