Effect of oxytocin on acute enkephalin tolerance in mice

H. Schwarzberg, G. Kovács, B. Penke, G. Telegdy

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Intracerebroventricular (i.c.v.) administration of a test dose of 0.5 μg D-Met2-Pro5-enkephalinamide (ENK) resulted in analgesia. Acute tolerance developed if a tolerance-inducing high dose of 5 μg ENK was administered i.c.v. prior to the test dose. Tolerance appeared as a reduction of the analgesic effect of the test dose. Subcutaneous (s.c.) injection of oxytocin (OXT) inhibited the development of tolerance. It is suggested that OXT is able to modify the development of tolerance to enkephalins, which are ligands of δ-opiate rather than μ-opiate receptors.

Original languageEnglish
Pages (from-to)247-250
Number of pages4
JournalNeuropeptides
Volume7
Issue number3
DOIs
Publication statusPublished - 1986

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Enkephalins
Oxytocin
Opiate Alkaloids
Opioid Receptors
Subcutaneous Injections
Analgesia
Analgesics
Ligands

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Clinical Neurology
  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

Cite this

Effect of oxytocin on acute enkephalin tolerance in mice. / Schwarzberg, H.; Kovács, G.; Penke, B.; Telegdy, G.

In: Neuropeptides, Vol. 7, No. 3, 1986, p. 247-250.

Research output: Contribution to journalArticle

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