Petefészekirtás és ösztrogénkezelés hatása intramurális koszorúserek biomechanikai és farmakológiai tulajdonságaira állatkísérletes modellben

Translated title of the contribution: Effect of oophorectomy and estrogen replacement therapy on the biomechanical and pharmacological properties of intramural coronary resistance in rat arteries

Metin Mericli, L. Nádasy György, Mária Szekeres, S. Várbíró, Z. Vajó, Máté Mátrai, N. Ács, E. Monos, B. Székács

Research output: Contribution to journalArticle

Abstract

Objective: We tested the hypothesis that female sex hormone depletion and estradiol replacement therapy significantly influences the bio-mechanical properties of intramural coronary resistance in arteries. Design: Female rats (N=30) were divided into three groups. Group A (OV) rats were subjected to bilateral oophorectomy. Group B (OV+E) rats were subjected to bilateral oophorectomy followed by estradiol replacement therapy. Rats in group C served as controls. One month after oophorectomy intramural coronary arteries (approximately 180 μm in diameter) branching from the left anterior descending coronary artery were isolated, cannulated and studied using microarteriography. Intraluminal pressure was inceased stepwise between 0 and 90 mmHg. The steady state diameter at each step was measured. These measurements were repeated in the presence of U46619, a thromboxane A2 receptor agonist (at a concentration of 10-6 M), and bradykinin (at 10-6 M). Finally, Ca2+-free Krebs-induced passive diameter was measured in each group. Results: Oophorectomy increased spontaneous nyogenic tone of the coronary arteries (p2 agonist induced the greatest contraction in the estrogen replacement group (p

Original languageHungarian
Pages (from-to)333-343
Number of pages11
JournalMagyar Noorvosok Lapja
Volume67
Issue number6
Publication statusPublished - 2004

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Estrogen Replacement Therapy
Ovariectomy
Arteries
Pharmacology
Coronary Vessels
Estradiol
Prostaglandin H2 Receptors Thromboxane A2
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Gonadal Steroid Hormones
Bradykinin
Pressure
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Petefészekirtás és ösztrogénkezelés hatása intramurális koszorúserek biomechanikai és farmakológiai tulajdonságaira állatkísérletes modellben. / Mericli, Metin; György, L. Nádasy; Szekeres, Mária; Várbíró, S.; Vajó, Z.; Mátrai, Máté; Ács, N.; Monos, E.; Székács, B.

In: Magyar Noorvosok Lapja, Vol. 67, No. 6, 2004, p. 333-343.

Research output: Contribution to journalArticle

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AU - Mericli, Metin

AU - György, L. Nádasy

AU - Szekeres, Mária

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AU - Vajó, Z.

AU - Mátrai, Máté

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AU - Monos, E.

AU - Székács, B.

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