Effect of NSAIDs on pupil diameter and expression of aqueous humor cytokines in FLACS versus conventional phacoemulsification

Natalia S. Anisimova, Lisa B. Arbisser, G. Petrovski, Svetlana V. Petrichuk, Nikolay P. Sobolev, Beata Petrovski, Sergey A. Borsenok, Yurii A. Komah, Boris E. Malyugin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: To compare the concentrations of interleukin (IL) (IL-1b, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70), interferon (IFN)-g, tumor necrosis factor (TNF)-a, and TNF-b in the aqueous humor of patients undergoing femtosecond laser-assisted cataract surgery (FLACS) and corneal mechanical paracentesis treated with two different topical nonsteroidal anti-inflammatory drugs (NSAIDs): bromfenac and indomethacin. Methods: In this prospective, randomized controlled, single-center study, aqueous humor samples were obtained immediately after performing the femtosecond laser procedure or at the start of conventional phacoemulsification. Preoperatively, the FLACS groups were administered (once daily and four times daily, respectively) either topical bromfenac 0.09% (12 eyes) or indomethacin 0.1% (12 eyes). The corneal paracentesis bromfenac and indomethacin groups received the same regimen of instillation of NSAIDs, respectively. Quantitative analysis of the expressed cytokines in the aqueous humor was performed using FlowCytomix FC 500 Pro 3.0 Software (Bender MedSystems GmbH, Vienna, Austria). Results: The intraoperative pupil diameter was correlated with the expression of IL-6 after the femtosecond laser procedure in the FLACS indomethacin group (r = -0.53; P = .07). A significant difference in mean pupillary size was detected between the FLACS bromfenac and indomethacin groups at the aspiration/irrigation time point (0.53 ± 0.26 mm) and at the end of surgery (0.68 ± 0.37 mm). Progressive pupillary constriction was observed in the indomethacin and bromfenac groups. Conclusions: A smaller expression of IL-6 to the overall cytokine network value was observed in cases receiving preoperative bromfenac 0.09%, explaining improved maintenance of intraoperative mydriasis.

Original languageEnglish
Pages (from-to)646-652
Number of pages7
JournalJournal of Refractive Surgery
Volume34
Issue number10
DOIs
Publication statusPublished - Oct 1 2018

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Phacoemulsification
Aqueous Humor
Pupil
Indomethacin
Cataract
Lasers
Anti-Inflammatory Agents
Cytokines
Interleukins
Pharmaceutical Preparations
Paracentesis
Interleukin-6
Tumor Necrosis Factor-alpha
Mydriasis
Austria
Interleukin-5
Interleukin-8
Constriction
Interleukin-4
Interleukin-10

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

Cite this

Effect of NSAIDs on pupil diameter and expression of aqueous humor cytokines in FLACS versus conventional phacoemulsification. / Anisimova, Natalia S.; Arbisser, Lisa B.; Petrovski, G.; Petrichuk, Svetlana V.; Sobolev, Nikolay P.; Petrovski, Beata; Borsenok, Sergey A.; Komah, Yurii A.; Malyugin, Boris E.

In: Journal of Refractive Surgery, Vol. 34, No. 10, 01.10.2018, p. 646-652.

Research output: Contribution to journalArticle

Anisimova, NS, Arbisser, LB, Petrovski, G, Petrichuk, SV, Sobolev, NP, Petrovski, B, Borsenok, SA, Komah, YA & Malyugin, BE 2018, 'Effect of NSAIDs on pupil diameter and expression of aqueous humor cytokines in FLACS versus conventional phacoemulsification', Journal of Refractive Surgery, vol. 34, no. 10, pp. 646-652. https://doi.org/10.3928/1081597X-20180814-02
Anisimova, Natalia S. ; Arbisser, Lisa B. ; Petrovski, G. ; Petrichuk, Svetlana V. ; Sobolev, Nikolay P. ; Petrovski, Beata ; Borsenok, Sergey A. ; Komah, Yurii A. ; Malyugin, Boris E. / Effect of NSAIDs on pupil diameter and expression of aqueous humor cytokines in FLACS versus conventional phacoemulsification. In: Journal of Refractive Surgery. 2018 ; Vol. 34, No. 10. pp. 646-652.
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abstract = "Purpose: To compare the concentrations of interleukin (IL) (IL-1b, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70), interferon (IFN)-g, tumor necrosis factor (TNF)-a, and TNF-b in the aqueous humor of patients undergoing femtosecond laser-assisted cataract surgery (FLACS) and corneal mechanical paracentesis treated with two different topical nonsteroidal anti-inflammatory drugs (NSAIDs): bromfenac and indomethacin. Methods: In this prospective, randomized controlled, single-center study, aqueous humor samples were obtained immediately after performing the femtosecond laser procedure or at the start of conventional phacoemulsification. Preoperatively, the FLACS groups were administered (once daily and four times daily, respectively) either topical bromfenac 0.09{\%} (12 eyes) or indomethacin 0.1{\%} (12 eyes). The corneal paracentesis bromfenac and indomethacin groups received the same regimen of instillation of NSAIDs, respectively. Quantitative analysis of the expressed cytokines in the aqueous humor was performed using FlowCytomix FC 500 Pro 3.0 Software (Bender MedSystems GmbH, Vienna, Austria). Results: The intraoperative pupil diameter was correlated with the expression of IL-6 after the femtosecond laser procedure in the FLACS indomethacin group (r = -0.53; P = .07). A significant difference in mean pupillary size was detected between the FLACS bromfenac and indomethacin groups at the aspiration/irrigation time point (0.53 ± 0.26 mm) and at the end of surgery (0.68 ± 0.37 mm). Progressive pupillary constriction was observed in the indomethacin and bromfenac groups. Conclusions: A smaller expression of IL-6 to the overall cytokine network value was observed in cases receiving preoperative bromfenac 0.09{\%}, explaining improved maintenance of intraoperative mydriasis.",
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T1 - Effect of NSAIDs on pupil diameter and expression of aqueous humor cytokines in FLACS versus conventional phacoemulsification

AU - Anisimova, Natalia S.

AU - Arbisser, Lisa B.

AU - Petrovski, G.

AU - Petrichuk, Svetlana V.

AU - Sobolev, Nikolay P.

AU - Petrovski, Beata

AU - Borsenok, Sergey A.

AU - Komah, Yurii A.

AU - Malyugin, Boris E.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Purpose: To compare the concentrations of interleukin (IL) (IL-1b, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70), interferon (IFN)-g, tumor necrosis factor (TNF)-a, and TNF-b in the aqueous humor of patients undergoing femtosecond laser-assisted cataract surgery (FLACS) and corneal mechanical paracentesis treated with two different topical nonsteroidal anti-inflammatory drugs (NSAIDs): bromfenac and indomethacin. Methods: In this prospective, randomized controlled, single-center study, aqueous humor samples were obtained immediately after performing the femtosecond laser procedure or at the start of conventional phacoemulsification. Preoperatively, the FLACS groups were administered (once daily and four times daily, respectively) either topical bromfenac 0.09% (12 eyes) or indomethacin 0.1% (12 eyes). The corneal paracentesis bromfenac and indomethacin groups received the same regimen of instillation of NSAIDs, respectively. Quantitative analysis of the expressed cytokines in the aqueous humor was performed using FlowCytomix FC 500 Pro 3.0 Software (Bender MedSystems GmbH, Vienna, Austria). Results: The intraoperative pupil diameter was correlated with the expression of IL-6 after the femtosecond laser procedure in the FLACS indomethacin group (r = -0.53; P = .07). A significant difference in mean pupillary size was detected between the FLACS bromfenac and indomethacin groups at the aspiration/irrigation time point (0.53 ± 0.26 mm) and at the end of surgery (0.68 ± 0.37 mm). Progressive pupillary constriction was observed in the indomethacin and bromfenac groups. Conclusions: A smaller expression of IL-6 to the overall cytokine network value was observed in cases receiving preoperative bromfenac 0.09%, explaining improved maintenance of intraoperative mydriasis.

AB - Purpose: To compare the concentrations of interleukin (IL) (IL-1b, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70), interferon (IFN)-g, tumor necrosis factor (TNF)-a, and TNF-b in the aqueous humor of patients undergoing femtosecond laser-assisted cataract surgery (FLACS) and corneal mechanical paracentesis treated with two different topical nonsteroidal anti-inflammatory drugs (NSAIDs): bromfenac and indomethacin. Methods: In this prospective, randomized controlled, single-center study, aqueous humor samples were obtained immediately after performing the femtosecond laser procedure or at the start of conventional phacoemulsification. Preoperatively, the FLACS groups were administered (once daily and four times daily, respectively) either topical bromfenac 0.09% (12 eyes) or indomethacin 0.1% (12 eyes). The corneal paracentesis bromfenac and indomethacin groups received the same regimen of instillation of NSAIDs, respectively. Quantitative analysis of the expressed cytokines in the aqueous humor was performed using FlowCytomix FC 500 Pro 3.0 Software (Bender MedSystems GmbH, Vienna, Austria). Results: The intraoperative pupil diameter was correlated with the expression of IL-6 after the femtosecond laser procedure in the FLACS indomethacin group (r = -0.53; P = .07). A significant difference in mean pupillary size was detected between the FLACS bromfenac and indomethacin groups at the aspiration/irrigation time point (0.53 ± 0.26 mm) and at the end of surgery (0.68 ± 0.37 mm). Progressive pupillary constriction was observed in the indomethacin and bromfenac groups. Conclusions: A smaller expression of IL-6 to the overall cytokine network value was observed in cases receiving preoperative bromfenac 0.09%, explaining improved maintenance of intraoperative mydriasis.

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